{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:08:55Z","timestamp":1789898935776,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T00:00:00Z","timestamp":1419897600000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Early tumor recurrence, either local or intrahepatic distant recurrence (<jats:styled-content style=\"fixed-case\">IDR<\/jats:styled-content>), after successful radiofrequency ablation (<jats:styled-content style=\"fixed-case\">RFA<\/jats:styled-content>) for hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>) remains a significant problem. The study aimed to determine the potential risk factors for <jats:styled-content style=\"fixed-case\">IDR<\/jats:styled-content> within one year after successful <jats:styled-content style=\"fixed-case\">RFA<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 105 patients with 138 lesions who underwent <jats:styled-content style=\"fixed-case\">RFA<\/jats:styled-content> and were followed up for at least one year were included in this study. The patients' data was retrospectively reviewed. Multiple host and tumoral potential risk factors were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IDR was found in 62 (59.0%) of all patients. Cumulative <jats:styled-content style=\"fixed-case\">IDR<\/jats:styled-content>\u2010free survival rates in all patients studied were 81.9%, 45.4% and 35.2% at 1, 2 and 3 years, respectively, after <jats:styled-content style=\"fixed-case\">RFA<\/jats:styled-content>. Univariate and multivariate analysis showed that both tumor size &gt;2.8\u2009cm and primary multinodular tumors were significant risk factors for <jats:styled-content style=\"fixed-case\">IDR<\/jats:styled-content> within one year after RFA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with tumors of &gt;2.8\u2009cm in diameter or multinodular <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> should be closely monitored for early recurrence after <jats:styled-content style=\"fixed-case\">RFA<\/jats:styled-content>. Combined or systemic therapies should be tried for these patients to improve their disease\u2010free and overall survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12190","type":"journal-article","created":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T04:48:57Z","timestamp":1410497337000},"page":"676-683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Risk factors for early intrahepatic distant recurrence after radiofrequency ablation for hepatocellular carcinoma in <scp>E<\/scp>gyptian patients"],"prefix":"10.1111","volume":"15","author":[{"given":"Mohammed Fawzy","family":"Montasser","sequence":"first","affiliation":[{"name":"Department of Tropical Medicine Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Kamal","family":"Shaker","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf M","family":"Albreedy","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman Fawzy","family":"Montasser","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"El Dorry","sequence":"additional","affiliation":[{"name":"Intervention Radiology Department Faculty of Medicine Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds225"},{"key":"e_1_2_6_3_1","unstructured":"Egypt National Cancer Registry. 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