{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:28:13Z","timestamp":1771655293705,"version":"3.50.1"},"reference-count":68,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T00:00:00Z","timestamp":1414972800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>Anti\u2010tumor necrosis factor (TNF)\u2010\u03b1 agents emerge as the hot spot in the last decade for treating patients with inflammatory bowel disease (<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>). The effect of anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 agents is satisfactory; however, some patients fail to achieve clinical response. Fortunately, in recent years, great efforts have been made and multiple novel therapies have been developed in the treatment for <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>. In this article, we aim to introduce anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 drugs as well as other novel treatments currently undergoing clinical trials for <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1751-2980.12193","type":"journal-article","created":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T08:43:16Z","timestamp":1411548196000},"page":"585-590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Novel agents in the future: Therapy beyond anti\u2010TNF agents in inflammatory bowel disease"],"prefix":"10.1111","volume":"15","author":[{"given":"Jiang Chen","family":"Peng","sequence":"first","affiliation":[{"name":"State Key Laboratory for Oncogenes and Related Genes Key Laboratory of Gastroenterology and Hepatology Ministry of Health Division of Gastroenterology and Hepatology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai Inflammatory Bowel Disease Research Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Oncogenes and Related Genes Key Laboratory of Gastroenterology and Hepatology Ministry of Health Division of Gastroenterology and Hepatology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai Inflammatory Bowel Disease Research Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi Hua","family":"Ran","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Oncogenes and Related Genes Key Laboratory of Gastroenterology and Hepatology Ministry of Health Division of Gastroenterology and Hepatology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai Inflammatory Bowel Disease Research Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06005"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.51.1.289"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000289195"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10209"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199710093371502"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199905063401804"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08512-4"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030815"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.363"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1361.100"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2004.07.012"},{"key":"e_1_2_12_13_1","first-page":"109","article-title":"Sequential therapies for Crohn's disease: optimizing conventional and biologic strategies","volume":"8","author":"Desilva S","year":"2008","journal-title":"Rev Gastroenterol Disord"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.4263"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050516"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.06.061"},{"key":"e_1_2_12_17_1","first-page":"763","article-title":"Adalimumab for the treatment of Crohn's disease","volume":"2","author":"Cassinotti A","year":"2008","journal-title":"Biologics"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.030"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-12-200706190-00159"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.01.035"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.106781"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.159251"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.05.048"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2014.885945"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067594"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062897"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006893"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006097.pub2"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051847"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051782"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042982"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.06.007"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21896"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i35.5606"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0107-26"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1001"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28508"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104758"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.07.014"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60725-4"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60726-6"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X120931"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203572"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2013.06.007"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112168"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.749"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.079392"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.079434"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21038"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2012.12.004"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2013.843743"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2863"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.01.012"},{"key":"e_1_2_12_54_1","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.4049\/jimmunol.151.7.3460","article-title":"Combination IL\u20102 and IL\u20104 reduces glucocorticoid receptor\u2010binding affinity and T cell response to glucocorticoids","volume":"151","author":"Kam JC","year":"1993","journal-title":"J Immunol"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(01)00023-5"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.13.7319"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.5.2050"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.122465"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02904.x"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.04.043"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(02)05907-5"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.089854"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.11.009"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.225482"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e32835d7bba"},{"key":"e_1_2_12_66_1","first-page":"606","article-title":"Efficacy of probiotics for the management of inflammatory bowel disease","volume":"7","author":"Sartor RB","year":"2011","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)80068-P"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.03.028"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-food-022510-133640"}],"container-title":["Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1751-2980.12193","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-2980.12193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T14:51:26Z","timestamp":1696344686000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1751-2980.12193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":68,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1111\/1751-2980.12193"],"URL":"https:\/\/doi.org\/10.1111\/1751-2980.12193","archive":["Portico"],"relation":{},"ISSN":["1751-2972","1751-2980"],"issn-type":[{"value":"1751-2972","type":"print"},{"value":"1751-2980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"2014-11-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}