{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:39:40Z","timestamp":1779302380527,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T00:00:00Z","timestamp":1419897600000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81270506"],"award-info":[{"award-number":["81270506"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81072003"],"award-info":[{"award-number":["81072003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>aris criteria, the revised diagnostic criteria and the simplified diagnostic scoring system in the diagnosis of primary biliary cirrhosis (<jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content>)\u2013autoimmune hepatitis (<jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>) overlap syndrome in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of the patients who were diagnosed with <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content> at the Union Hospital and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>ongji Hospital, Tongji Medical University, Huazhong University of Science and Technology (<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>uhan, <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ubei <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>rovince, <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hina) from 2003 to 2012 were retrospectively reviewed. The overlap syndrome was diagnosed based on the <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>aris criteria, the revised criteria and the simplified criteria, respectively. Patients' clinical characteristics, laboratory examination results and histological findings were collected. The sensitivity and specificity of the three criteria for diagnosing <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> overlap syndrome were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> overlap syndrome was diagnosed in 2, 13 and 10 patients with <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content> based on the <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>aris, the revised and the simplified criteria, respectively. The sensitivity and specificity of the simplified criteria in diagnosing the overlap syndrome was 90.0% and 98.2%, which were the highest among the three criteria, followed by the revised criteria. The <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>aris criteria showed a high specificity (100%) but a relatively low sensitivity (20.0%). In addition, some patients who did not fulfil the <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>aris criteria still benefited from the immunosuppressive agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese patients with the <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> overlap syndrome, the simplified criteria appear to be the most efficacious compared with the <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>aris criteria and the revised criteria. Further studies should be performed to confirm these observations with respect to long\u2010term outcomes and therapeutic implications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12196","type":"journal-article","created":{"date-parts":[[2014,9,19]],"date-time":"2014-09-19T08:27:39Z","timestamp":1411115259000},"page":"660-668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Primary biliary cirrhosis\u2013autoimmune hepatitis overlap syndrome: Simplified criteria may be effective in the diagnosis in <scp>C<\/scp>hinese patients"],"prefix":"10.1111","volume":"15","author":[{"given":"Fang","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen Guo","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Huai'an First People's Hospital Nanjing Medical University  Huai'an Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Organ Transplantation Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  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