{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T13:08:12Z","timestamp":1773752892313,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T00:00:00Z","timestamp":1424736000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to evaluate the efficacy of liver stiffness measurement (<jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content>) in predicting the presence and severity of esophageal varices (<jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content>) and investigating its association with liver function (LF) in patients with liver cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of 90 cirrhotic patients who underwent <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> by transient elastography were retrospectively reviewed. The relationship between <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> and the presence and severity of <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content> was evaluated by esophagogastroduodenoscopy (<jats:styled-content style=\"fixed-case\">EGD<\/jats:styled-content>) and multislice spiral computed tomography (MS<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>). Another 25 healthy individuals were included as controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> was significantly associated with the Child\u2013Pugh score in cirrhotic patients, with the highest <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> in those with Child\u2013Pugh <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>. Patients with clinically decompensated cirrhosis had a higher <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> than those with compensated cirrhosis (36.75\u2009\u00b1\u200916.54\u2009kPa <jats:italic>vs<\/jats:italic> 17.65\u2009\u00b1\u200910.87\u2009kPa, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). However, there was no significant difference in <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> value between patients with severe <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content> and those with no or non\u2010severe <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content> determined by endoscopy (28.18 \u00b1 17.44\u2009kPa <jats:italic>vs<\/jats:italic> 31.00 \u00b1 18.44\u2009kPa) or MS<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> (29.71\u2009\u00b1\u200918.39\u2009kPa <jats:italic>vs<\/jats:italic> 24.90\u2009\u00b1\u200914.80\u2009kPa). The diagnostic value of <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> for predicting severe <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content> was low in unselected cirrhotic patients. The presence of <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content> examined by <jats:styled-content style=\"fixed-case\">EGD<\/jats:styled-content> and MS<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> was similar to each other.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> could be used to evaluate the progression of liver cirrhosis continuously. However, its role in assessing <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content> grades in advanced cirrhosis needs further confirmation. MS<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> can assess <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content> accurately and may serve as an alternative to endoscopy in the assessment of portal hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12210","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T08:07:20Z","timestamp":1415693240000},"page":"98-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The role of liver stiffness measurement in the evaluation of liver function and esophageal varices in cirrhotic patients"],"prefix":"10.1111","volume":"16","author":[{"given":"Jing","family":"Hua","sequence":"first","affiliation":[{"name":"Key Laboratory of Gastroenterology &amp; Hepatology Ministry of Health Division of Gastroenterology and Hepatology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui Qin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Bao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Gastroenterology &amp; Hepatology Ministry of Health Division of Gastroenterology and Hepatology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Sheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Gastroenterology &amp; Hepatology Ministry of Health Division of Gastroenterology and Hepatology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can Jie","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Gastroenterology &amp; Hepatology Ministry of Health Division of Gastroenterology and Hepatology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Gastroenterology &amp; Hepatology Ministry of Health Division of Gastroenterology and Hepatology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Gastroenterology &amp; Hepatology Ministry of Health Division of Gastroenterology and Hepatology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia Lin","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Radiology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.23054"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80320-7"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.1539_a.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.8.1200"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03701.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21665"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.02.008"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20506"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.01.034"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.08.018"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03825.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2010.01375.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.04.006"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.01.051"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.06.027"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.05.1737"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.07.033"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-5926-3-8"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.11.018"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.160"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.07.005"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.069153"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01191.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21563"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095776"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2423050784"}],"container-title":["Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1751-2980.12210","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-2980.12210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T21:08:01Z","timestamp":1696280881000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1751-2980.12210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/1751-2980.12210"],"URL":"https:\/\/doi.org\/10.1111\/1751-2980.12210","archive":["Portico"],"relation":{},"ISSN":["1751-2972","1751-2980"],"issn-type":[{"value":"1751-2972","type":"print"},{"value":"1751-2980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"2015-02-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}