{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T03:41:09Z","timestamp":1793418069681,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T00:00:00Z","timestamp":1424736000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Ecabet sodium (ES) is a new non\u2010systemic anti\u2010ulcer agent belonging to the category of gastroprotective agents. In this study we aimed to compare the efficacy of a combination therapy with lansoprazole (<jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>) followed by <jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> alone in treating endoscopic submucosal dissection (<jats:styled-content style=\"fixed-case\">ESD<\/jats:styled-content>)\u2010induced iatrogenic gastric ulcers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed with gastric adenomas or early gastric cancer were randomly divided into either the <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> group (30\u2009mg once daily for 4 weeks; <jats:italic>n<\/jats:italic>\u2009=\u200945) or the <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>\u2009+\u2009<jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content> group (<jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> 30\u2009mg once daily for one week followed by\u2009<jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content> 1500\u2009mg twice daily for 3 weeks; <jats:italic>n<\/jats:italic>\u2009=\u200945). Four weeks after ESD, a follow\u2010up endoscopy was conducted to evaluate the proportions of ulcer reduction and ulcer stages in the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 79 patients were included in the final analyses. Both treatment modalities were well\u2010tolerated in most patients, with a drug compliance of over 80%. There were no significant differences between the two groups in terms of the proportions of ulcer reduction (0.9503\u2009\u00b1\u20090.1215 in the <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> group <jats:italic>vs<\/jats:italic> 0.9192\u2009\u00b1\u20090.0700 in the <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>\u2009+\u2009<jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content> group, <jats:italic>P<\/jats:italic>\u2009=\u20090.169) or ulcer stage (<jats:italic>P<\/jats:italic>\u2009=\u20090.446). The prevalence of adverse events related to drugs and bleeding were also similar between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sequential therapy with <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>\u2009+\u2009<jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content> is as effective as <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> alone against <jats:styled-content style=\"fixed-case\">ESD<\/jats:styled-content>\u2010induced gastric ulcers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12214","type":"journal-article","created":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T04:02:53Z","timestamp":1416888173000},"page":"75-82","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The effect of sequential therapy with lansoprazole and ecabet sodium in treating iatrogenic gastric ulcer after endoscopic submucosal dissection: A randomized prospective study"],"prefix":"10.1111","volume":"16","author":[{"given":"Ji Yong","family":"Ahn","sequence":"first","affiliation":[{"name":"Department of Gastroenterology University of Ulsan College of Medicine, Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Hwan","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chung\u2010Ang University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang Wook","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chung\u2010Ang University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chung\u2010Ang University College of Medicine  Seoul 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