{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:59:38Z","timestamp":1780491578076,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T00:00:00Z","timestamp":1430265600000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the determinants of long\u2010term outcome in patients with spontaneous bacterial peritonitis (<jats:styled-content style=\"fixed-case\">SBP)<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was conducted retrospectively. <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>aplan\u2013<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>eier (<jats:styled-content style=\"fixed-case\">KM)<\/jats:styled-content> and Cox proportional hazards survival analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Altogether, 93 patients with <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content> were identified, with their mean age of 57.9\u2009\u00b1\u200912.9 years, <jats:styled-content style=\"fixed-case\">Child\u2013Pugh<\/jats:styled-content> score 10.4\u2009\u00b1\u20091.9 and model for end\u2010stage liver disease (<jats:styled-content style=\"fixed-case\">MELD)<\/jats:styled-content> score 20.2\u2009\u00b1\u20096.8. The etiology of chronic liver disease (<jats:styled-content style=\"fixed-case\">CLD<\/jats:styled-content>) was alcohol\u2010related liver disease (<jats:styled-content style=\"fixed-case\">ARLD<\/jats:styled-content>) (<jats:italic>n<\/jats:italic>\u2009=\u200958) and viral hepatitis\/non\u2010alcoholic steatohepatitis (<jats:italic>n<\/jats:italic>\u2009=\u200928). <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content> was the index presentation of cirrhosis in 26 (28.0%) patients. Overall mortality was 80.6%; among them 81.3% were liver\u2010related, and 33 (35.5%) died during index hospitalization. In total, 70.0% of patients who survived index hospitalization died during follow\u2010up, with a median survival of 12.5 months. Estimated survival at 3 months, 1 year and 5 years was 54.8%, 34.4% and 15.2%, respectively. Non\u2010<jats:styled-content style=\"fixed-case\">ARLD<\/jats:styled-content> etiology for <jats:styled-content style=\"fixed-case\">CLD<\/jats:styled-content> was an independent predictor of overall mortality (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 3.484, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.802\u20136.757, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and mortality in those surviving hospitalization (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 2.319, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.210\u20134.444, <jats:italic>P<\/jats:italic>\u2009=\u20090.011). Hepatorenal syndrome did not predict outcomes. Two (3.3%) patients surviving hospitalization underwent liver transplantation (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>One\u2010year survival after hospitalization with <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content> remains poor (34.4%) with unacceptably low LT rates. Non\u2010<jats:styled-content style=\"fixed-case\">ARLD<\/jats:styled-content> etiology for <jats:styled-content style=\"fixed-case\">CLD<\/jats:styled-content> is an independent predictor of both overall mortality and mortality after discharge. In view of the projected increase in non\u2010alcoholic steatohepatitis\u2010related CLD, screening strategies for timely <jats:styled-content style=\"fixed-case\">CLD<\/jats:styled-content> diagnosis are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12228","type":"journal-article","created":{"date-parts":[[2015,1,7]],"date-time":"2015-01-07T08:55:38Z","timestamp":1420620938000},"page":"228-240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Long\u2010term outcomes after hospitalization with spontaneous bacterial peritonitis"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6544-9218","authenticated-orcid":false,"given":"Kok Haw Jonathan","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology Brighton &amp; Sussex University Hospitals NHS Trust  Brighton United 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