{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:38:54Z","timestamp":1777941534489,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T00:00:00Z","timestamp":1432771200000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No.30872973"],"award-info":[{"award-number":["No.30872973"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to investigate the prevalence of colorectal neoplasms in patients coronary artery disease (<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>) with or without a family history of colorectal cancer (<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional study, individuals with suspected <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> in the absence of cancer\u2010related symptoms underwent coronary angiography for the first time, and were divided into <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> groups. Colonoscopy was performed in individuals at high\u2010risk tier based on their <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sia\u2013<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>acific colorectal screening (<jats:styled-content style=\"fixed-case\">APCS<\/jats:styled-content>) score. Their waist circumference (WC), height and body weight were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 634 of 1157 individuals at a high risk of developing advanced colorectal neoplasms, 91.0% (577\/634) of whom were male smokers. The proportion of <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> patients in the high\u2010risk tier was 81.5% (517\/634), while the prevalences of adenomas (32.1% <jats:italic>vs<\/jats:italic> 22.2%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and advanced adenomas (14.7% <jats:italic>vs<\/jats:italic> 8.5%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) were significantly higher in the <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> group than in the non\u2010<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> group. After 83 individuals with a family history of <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> were excluded, only the prevalence of adenomas was still significantly higher in the <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> group than in the non\u2010<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> group (25.5% <jats:italic>vs<\/jats:italic> 16.0%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) \u226525\u2009kg\/m<jats:sup>2<\/jats:sup> was correlated with the occurrence of adenomas (OR\u20092.133, 95% CI 1.219\u20133.730, <jats:italic>P<\/jats:italic>\u2009=\u20090.008) in <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Even in the absence of family history of <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> patients at a high risk of developing advanced colorectal neoplasms classified by the <jats:styled-content style=\"fixed-case\">APCS<\/jats:styled-content> score still showed a remarkably high prevalence of colorectal adenomas. Moreover, the association between the occurrence of adenomas and <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> was stronger in overweight (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u2009\u226525\u2009kg\/m<jats:sup>2<\/jats:sup>) individuals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12243","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T06:15:52Z","timestamp":1426140952000},"page":"272-278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence of colorectal neoplasm in <scp>C<\/scp>hinese patients with high\u2010risk coronary artery disease classified by the <scp>A<\/scp>sia\u2013<scp>P<\/scp>acific <scp>C<\/scp>olorectal <scp>S<\/scp>creening score"],"prefix":"10.1111","volume":"16","author":[{"given":"Xiao Bo","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Geriatrics Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing Ling","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen Ying","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li Fen","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-009-0065-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr337"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncponc1107"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.12.1412"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06330.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.221168"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.6.2645"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1256317"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-6646(11)60016-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.180"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e328351c775"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.12.050"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.430"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2013.02.004"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060366"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-5-200703060-00009"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61049-0"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-012-1601-9"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-12-36"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.64"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i7.1858"}],"container-title":["Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1751-2980.12243","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-2980.12243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T06:45:22Z","timestamp":1696315522000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1751-2980.12243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/1751-2980.12243"],"URL":"https:\/\/doi.org\/10.1111\/1751-2980.12243","archive":["Portico"],"relation":{},"ISSN":["1751-2972","1751-2980"],"issn-type":[{"value":"1751-2972","type":"print"},{"value":"1751-2980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"2015-05-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}