{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T01:24:35Z","timestamp":1764811475681,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T00:00:00Z","timestamp":1439769600000},"content-version":"vor","delay-in-days":47,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2015,7]]},"abstract":"Objective<\/jats:title>Endoscopic submucosal dissection (ESD<\/jats:styled-content>) is commonly performed as a treatment for gastric neoplasms. However, sedation with midazolam (MDZ<\/jats:styled-content>) often does not reach satisfactory sedation levels during the procedure and the drug may suppress respiration and blood pressure. This study aimed to investigate the safety and efficacy of dexmedetomidine (DEX<\/jats:styled-content>) with on\u2010demand MDZ<\/jats:styled-content> (the DEX<\/jats:styled-content> group) in comparison with MDZ<\/jats:styled-content> alone (the MDZ<\/jats:styled-content> group) as a sedative during ESD<\/jats:styled-content> of gastric neoplasms.<\/jats:p><\/jats:sec>Methods<\/jats:title>Eighty patients undergoing ESD<\/jats:styled-content> for gastric tumor were randomly assigned to one of two treatment regimens (40 patients in each). We investigated the depth of sedation by using a Modified Observers Assessment Alertness\/Sedation score, the number of patients' reactions interfering with the procedure, sedation related\u2010adverse events and the degree of satisfaction of patients and doctors.<\/jats:p><\/jats:sec>Results<\/jats:title>There was no statistically significant difference between the two groups regarding their age, gender, body mass index, American Society of Anesthesiologists physical status classification and the characteristics of the tumor. Appropriate sedation rate and the degree of satisfaction of the doctors were significantly higher in the DEX<\/jats:styled-content> group than in the MDZ<\/jats:styled-content> group. Patients' reactions interfering with the procedure were more numerous in the MDZ<\/jats:styled-content> group than in the DEX<\/jats:styled-content> group. There was no significant difference in adverse events between the two groups.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>DEX<\/jats:styled-content> with on\u2010demand MDZ<\/jats:styled-content> for sedation during gastric ESD<\/jats:styled-content> is as safe as MDZ<\/jats:styled-content> alone and the sedation effect of DEX<\/jats:styled-content> with MDZ<\/jats:styled-content> is superior to that of MDZ<\/jats:styled-content> alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12254","type":"journal-article","created":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T09:07:19Z","timestamp":1430816839000},"page":"377-384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Comparison of dexmedetomidine with on\u2010demand midazolam versus<\/i> midazolam alone for procedural sedation during endoscopic submucosal dissection of gastric tumor"],"prefix":"10.1111","volume":"16","author":[{"given":"Sang Pyo","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Digestive Disease Center Konkuk University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3848-5571","authenticated-orcid":false,"given":"In\u2010Kyung","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Digestive Disease Center Konkuk University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Digestive Disease Center Konkuk University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun\u2010Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Digestive Disease Center Konkuk University School of Medicine Seoul 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