{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T09:46:01Z","timestamp":1771926361350,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T00:00:00Z","timestamp":1441843200000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>With an increased use of endoscopic retrograde cholangiopancreatography (<jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content>), post\u2010ERCP complications have attracted much attention. We aimed to identify independent risk factors of post\u2010<jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content> pancreatitis (<jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content>) and hyperamylasemia, and to develop a simple scoring system of the factors contributing to the clinical prevention against <jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective single\u2010center analysis was performed in 4234 <jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content> procedures between <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>eptember 2007 and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2012. Patient\u2010related and procedure\u2010related risk factors for <jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content> and post\u2010ERCP hyperamylasemia were identified by univariate and multivariate regression analyses. A scoring system was developed based on the independent risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content> occurred in 226 (5.3%) <jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content> procedures and hyperamylasemia in 774 (18.3%) procedures. Female gender (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>] 1.449), first\u2010time <jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.745), latent jaundice (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.917), difficult cannulation (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.317) and pancreatography (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.823) were all proven to be significant risk factors for predicting <jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content>. In addition, difficult cannulation (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.990) and pancreatography (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.009), age\u2009&lt;60 years (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.294), prior diabetes (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.614), biliary duct stent placement (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.884) and nasobiliary drainage (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.613) were associated with developing hyperamylasemia. Prophylactic pancreatic duct stent (<jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>) might prevent against <jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content> in significantly high\u2010risk patients (score\u2009\u22656).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both patient\u2010related and procedure\u2010related risk factors are important for predicting <jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content> and post\u2010ERCP hyperamylasemia. Technical procedures, for example, <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>, are necessary to prevent <jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content> in patients at the highest risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12258","type":"journal-article","created":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T11:16:13Z","timestamp":1431083773000},"page":"471-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Risk factors for post\u2010<scp>ERCP<\/scp> pancreatitis and hyperamylasemia: A retrospective single\u2010center study"],"prefix":"10.1111","volume":"16","author":[{"given":"Qi Bin","family":"He","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing 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