{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:56:21Z","timestamp":1790517381460,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T00:00:00Z","timestamp":1441843200000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The clinical spectrum of celiac disease (<jats:styled-content style=\"fixed-case\">CeD<\/jats:styled-content>) is wide and its symptoms overlap with those of functional bowel diseases. This study aimed to investigate the relationship among gluten\u2010related disorders, irritable bowel syndrome (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>) and uninvestigated dyspepsia in <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndian patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> and uninvestigated dyspepsia (using <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ome <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> criteria) were tested for immunoglobulin A (<jats:styled-content style=\"fixed-case\">IgA)<\/jats:styled-content> anti\u2010tissue transglutaminase (anti\u2010<jats:styled-content style=\"fixed-case\">tTG<\/jats:styled-content>) antibody and anti\u2010gliadin antibody (<jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content>). Those with positive anti\u2010<jats:styled-content style=\"fixed-case\">tTG<\/jats:styled-content> antibody were evaluated for the presence of villous abnormalities. Patients who were only <jats:styled-content style=\"fixed-case\">IgA AGA<\/jats:styled-content>\u2010positive were considered to have gluten sensitivity and those with positive anti\u2010<jats:styled-content style=\"fixed-case\">tTG<\/jats:styled-content> antibody and villous atrophy were considered to have <jats:styled-content style=\"fixed-case\">CeD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 362 patients with <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>, 22 (6.1%) had positive anti\u2010<jats:styled-content style=\"fixed-case\">tTG<\/jats:styled-content> antibody, among whom 3 (0.8%) had <jats:styled-content style=\"fixed-case\">CeD<\/jats:styled-content> and 19 had potential <jats:styled-content style=\"fixed-case\">CeD<\/jats:styled-content>. Of 358 patients with uninvestigated dyspepsia, 18 (5.0%) were anti\u2010<jats:styled-content style=\"fixed-case\">tTG<\/jats:styled-content> antibody\u2010positive and among them 4 (1.1%) had <jats:styled-content style=\"fixed-case\">CeD<\/jats:styled-content> and 14 had potential <jats:styled-content style=\"fixed-case\">CeD<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> was positive in 104 (28.7%) patients with <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> and 68 (19.0%) with uninvestigated dyspepsia, suggesting the presence of gluten sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study highlights the relationship between <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> or dyspepsia and <jats:styled-content style=\"fixed-case\">CeD<\/jats:styled-content> or gluten sensitivity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12260","type":"journal-article","created":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T11:16:29Z","timestamp":1431083789000},"page":"443-448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Prevalence of celiac disease in <scp>I<\/scp>ndian patients with irritable bowel syndrome and uninvestigated dyspepsia"],"prefix":"10.1111","volume":"16","author":[{"given":"Hanish","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Human Nutrition All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Human Nutrition All India Institute of Medical Sciences  New Delhi 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