{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:23:38Z","timestamp":1762521818887},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T00:00:00Z","timestamp":1443398400000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Objective<\/jats:title>The incidence of nonsteroidal anti\u2010inflammatory drugs (NSAIDs)\u2010induced enteropathy is currently increasing. However, the predictors of small bowel bleeding (SBB<\/jats:styled-content>) associated with NSAIDs<\/jats:styled-content> are unknown. This study aimed to assess the risk factors of SBB<\/jats:styled-content> in chronic NSAIDs<\/jats:styled-content> users.<\/jats:p><\/jats:sec>Methods<\/jats:title>We retrospectively compared the medical records of 147 patients receiving NSAID<\/jats:styled-content>s in a tertiary\u2010care setting (31 with SBB<\/jats:styled-content> and 116 without previous bleeding events) and analyzed the predictors of SBB<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>In total, 31 patients underwent video capsule endoscopy to detect SBB<\/jats:styled-content>, 74.2% of whom showed the evidence of SBB<\/jats:styled-content>. Non\u2010invasive treatment was performed in 90.3% of the patients. Multivariate logistic regression analysis revealed that the presence of coronary artery disease [adjusted odds ratio (aOR<\/jats:styled-content>) 12.43, 95% confidence interval (CI<\/jats:styled-content>) 1.19\u2013130.34, P<\/jats:italic>\u2009=\u20090.04], use of thienopyridine (aOR 16.93, 95% CI 3.78\u201375.72, P<\/jats:italic>\u2009<\u20090.001) and prior use of rebamipide (aOR<\/jats:styled-content> 0.31, 95% CI 0.12\u20130.82, P<\/jats:italic>\u2009=\u20090.02) were independently associated with SBB<\/jats:styled-content> in NSAIDs users.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Coronary artery disease and co\u2010use of thienopyridine were associated with SBB<\/jats:styled-content> in NSAIDs<\/jats:styled-content> users. The patients with coronary artery disease co\u2010using thienopyridine need to be monitored for the occurrence of SBB<\/jats:styled-content> when they were prescribed with NSAID<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12269","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T10:53:14Z","timestamp":1436179994000},"page":"499-504","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Risk factors for small bowel bleeding in chronic nonsteroidal anti\u2010inflammatory drug users"],"prefix":"10.1111","volume":"16","author":[{"given":"Kyu\u2010Man","family":"Cho","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Chonnam National University Hospital Gwangju 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