{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T23:15:27Z","timestamp":1792278927582,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T00:00:00Z","timestamp":1441843200000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Projects from the National Science Technology Pillar Program in the Twelfth Five-Year Plan Period, China","award":["2012BAI06B02)"],"award-info":[{"award-number":["2012BAI06B02)"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Antibiotic resistance to<jats:styled-content style=\"fixed-case\"><jats:italic>H<\/jats:italic><\/jats:styled-content><jats:italic>elicobacter pylori<\/jats:italic>(<jats:styled-content style=\"fixed-case\"><jats:italic>H<\/jats:italic><\/jats:styled-content><jats:italic>. pylori<\/jats:italic>) has been increasing worldwide. The study aimed to evaluate<jats:italic>in vitro<\/jats:italic>susceptibility and resistance patterns to antibiotics in empirical<jats:styled-content style=\"fixed-case\"><jats:italic>H<\/jats:italic><\/jats:styled-content><jats:italic>. pylori<\/jats:italic>eradication regimens, and to determine the optimal antibiotics for treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>H<\/jats:italic><\/jats:styled-content><jats:italic>. pylori<\/jats:italic>strains (<jats:italic>n<\/jats:italic>=181) were obtained from gastric biopsies of patients with upper gastrointestinal symptoms who underwent esophagogastroduodenoscopy from<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arch to<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2013. The susceptibility of<jats:styled-content style=\"fixed-case\"><jats:italic>H<\/jats:italic><\/jats:styled-content><jats:italic>. pylori<\/jats:italic>strains to amoxicillin (<jats:styled-content style=\"fixed-case\">AMX<\/jats:styled-content>), metronidazole (<jats:styled-content style=\"fixed-case\">MTZ<\/jats:styled-content>), clarithromycin (<jats:styled-content style=\"fixed-case\">CLR<\/jats:styled-content>), amoxicillin\u2010clavulanate (<jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content>), cephalothin (<jats:styled-content style=\"fixed-case\">CEP<\/jats:styled-content>), cefuroxime (<jats:styled-content style=\"fixed-case\">CXM<\/jats:styled-content>), cefixime (<jats:styled-content style=\"fixed-case\">CFM<\/jats:styled-content>), moxifloxacin (<jats:styled-content style=\"fixed-case\">MFX<\/jats:styled-content>) and minocycline (<jats:styled-content style=\"fixed-case\">MNO<\/jats:styled-content>) was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dual resistance to<jats:styled-content style=\"fixed-case\">MTZ<\/jats:styled-content>\u2009+\u2009<jats:styled-content style=\"fixed-case\">CLR<\/jats:styled-content>was detected in 48 (26.5%) isolates,<jats:styled-content style=\"fixed-case\">MTZ<\/jats:styled-content>\u2009+\u2009<jats:styled-content style=\"fixed-case\">MFX<\/jats:styled-content>in 94 (51.9%), and<jats:styled-content style=\"fixed-case\">CLR<\/jats:styled-content>\u2009+\u2009<jats:styled-content style=\"fixed-case\">MFX<\/jats:styled-content>in 49 (27.1%). Overall, 41 (22.7%) were resistant to<jats:styled-content style=\"fixed-case\">MTZ<\/jats:styled-content>\u2009+\u2009<jats:styled-content style=\"fixed-case\">CLR<\/jats:styled-content>\u2009+\u2009<jats:styled-content style=\"fixed-case\">MFX<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">MTZ<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">CLR<\/jats:styled-content>resistance rates were significantly associated with the history of<jats:italic>H. pylori<\/jats:italic>eradication but there was no significant difference in<jats:styled-content style=\"fixed-case\">MFX<\/jats:styled-content>resistance rates between treated and untreated patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.674). No significant relationship was found between antibiotic resistance and patient's gender, age, endoscopic findings, inflammatory severity or gastric atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">AMX<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">MNO<\/jats:styled-content>and cephalosporins, but not<jats:styled-content style=\"fixed-case\">MTZ<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">CLR<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">MFX<\/jats:styled-content>, showed good<jats:italic>in vitro<\/jats:italic>anti\u2010<jats:styled-content style=\"fixed-case\"><jats:italic>H<\/jats:italic><\/jats:styled-content><jats:italic>. pylori<\/jats:italic>activity. Among cephalosporins,<jats:styled-content style=\"fixed-case\">CXM<\/jats:styled-content>was the most active.<jats:styled-content style=\"fixed-case\"><jats:italic>H<\/jats:italic><\/jats:styled-content><jats:italic>. pylori<\/jats:italic>resistance is higher in patients with previous<jats:italic>H. pylori<\/jats:italic>eradication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12271","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T10:53:37Z","timestamp":1436180017000},"page":"464-470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Susceptibility of<scp><i>H<\/i><\/scp><i>elicobacter pylori<\/i>to antibiotics in<scp>C<\/scp>hinese patients"],"prefix":"10.1111","volume":"16","author":[{"given":"Peng","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital Beijing 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