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The literature has recorded only approximately one hundred cases in adults during the past two decades in whom malignancy is rarely associated with giant cell hepatitis. Our patient is a 66\u2010year\u2010old woman who was diagnosed with chronic lymphocytic leukemia (<jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>) and subsequently developed syncytial giant cell hepatitis. This disease is usually linked to virus infection, autoimmune diseases, and drug medications. The association between <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> and giant cell hepatitis is rare, with only three cases reported. In most cases viral particles on electron microscopy are reported and the patients usually have a history of chemotherapy and hypogammaglobulinemia. Unlike such cases, our patient developed giant cell hepatitis in the absence of such confounding variables. The treatment for our patient was a high\u2010dose corticosteroid and rituxan, with improvement in liver enzymes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12273","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T10:53:58Z","timestamp":1436180038000},"page":"683-688","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Syncytial giant cell hepatitis in a patient with chronic lymphocytic leukemia"],"prefix":"10.1111","volume":"16","author":[{"given":"Neil","family":"Gupta","sequence":"first","affiliation":[{"name":"Yale University School of Medicine  New Haven Connecticut, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basile","family":"Njei","sequence":"additional","affiliation":[{"name":"Yale University School of Medicine  New Haven Connecticut, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,29]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"601290","article-title":"Postinfantile giant cell hepatitis: an etiological and prognostic perspective","volume":"2013","author":"Bihari C","year":"2013","journal-title":"Hepat Res Treat"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80289-5"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02899924"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.4063"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0676.1996.tb00743.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.058560"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0676.1982.tb00839.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.meg.0000050026.34359.7c"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00548.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2326-12-8"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840160208"},{"key":"e_1_2_5_13_1","first-page":"1141","article-title":"Fatal liver necrosis due to allopurinol","volume":"11","author":"Pereira S","year":"1998","journal-title":"Acta Med Port"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90092-2"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.3350\/kjhep.2008.14.1.97"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199102143240705"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.7870"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2010.01.005"}],"container-title":["Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1751-2980.12273","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-2980.12273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T08:30:38Z","timestamp":1696321838000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1751-2980.12273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/1751-2980.12273"],"URL":"https:\/\/doi.org\/10.1111\/1751-2980.12273","archive":["Portico"],"relation":{},"ISSN":["1751-2972","1751-2980"],"issn-type":[{"value":"1751-2972","type":"print"},{"value":"1751-2980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"2015-12-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}