{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T09:18:09Z","timestamp":1773220689646,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T00:00:00Z","timestamp":1451347200000},"content-version":"vor","delay-in-days":58,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Science and Technology Guiding Plan of Shanghai","award":["124119a0702"],"award-info":[{"award-number":["124119a0702"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy, safety and tolerability of different doses of rifaximin in Chinese patients with liver cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This random prospective study included a screening visit, a 2\u2010week treatment period and a subsequent 4\u2010week observation phase. Patients with liver cirrhosis were randomly assigned to a low\u2010dose rifaximin group, a high\u2010dose rifaximin group and the control group in a ratio of 1:1:1. The low\u2010dose and high\u2010dose groups received 400\u2009mg or 600\u2009mg rifaximin per 12 h for 2 weeks, respectively. All other therapeutic strategies remained unchanged in the three groups as long as possible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 60 patients with liver cirrhosis were screened and 43 of them met the eligibility criteria. After 2\u2010week treatment serum endotoxin levels in the low\u2010dose (1.1\u2009\u00b1\u20090.8\u2009EU\/mL) and high\u2010dose rifaximin groups (1.0\u2009\u00b1\u20090.8\u2009EU\/mL) were significantly lower than that in the control group (2.5\u2009\u00b1\u20091.8\u2009EU\/mL), while no significant difference was found between the two rifaximin\u2010treated groups. The effect of high\u2010dose rifaximin on endotoxemia lasted for at least 4\u2009weeks after drug withdrawal. A significant reduction in the abundance of the <jats:italic>Veillonellaceae<\/jats:italic> taxa and an increase in the abundance of <jats:italic>Bacteroidaceae<\/jats:italic> were shown after 2 weeks of rifaximin therapy. The incidence of adverse events and severe adverse events was similar among the three groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low\u2010dose (800\u2009mg\/day) rifaximin could be analogous to high\u2010dose (1200\u2009mg\/day) rifaximin to reduce the serum endotoxin level after 2 weeks of treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12294","type":"journal-article","created":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T17:44:55Z","timestamp":1445017495000},"page":"665-674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Does low\u2010dose rifaximin ameliorate endotoxemia in patients with liver cirrhosis: a prospective study"],"prefix":"10.1111","volume":"16","author":[{"given":"Xin","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Shanghai Changzheng Hospital Second Military Medical University  Shanghai 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