{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:57:52Z","timestamp":1780509472886,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:00:00Z","timestamp":1461283200000},"content-version":"vor","delay-in-days":81,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To confirm the potential therapeutic efficacy of HAO472 against inflammatory bowel disease (IBD), we investigated the modulatory functions of HAO472 in a mouse model of trinitrobenzene sulfonic acid (TNBS)\u2010induced colitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Colitis was induced via an intrarectal injection of TNBS in mice. HAO472 (5.0 mg\/kg or 7.5 mg\/kg) or 1 mg\/kg dexamethasone (DX) was injected intraperitoneally into the mice after the TNBS administration. Behavioral and weight changes, macroscopic and histological assessments of colon, the expressions of tumor necrosis factor (TNF)\u2010\u03b1, interferon (IFN)\u2010\u03b3 and interleukin (IL)\u201017A, cyclooxygenase (COX)\u20102, inducible nitric oxide synthase (iNOS) and nuclear factor\u2010kappa B (NF\u2010\u03baB) in the colonic tissues were evaluated. The effect of HAO472 on NF\u2010\u03baB signaling pathway in lymphocytes was also invesigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HAO472 significantly ameliorated the clinical symptoms, reduced the severity of the inflammation and decreased mortality in the mouse model. HAO472 also reduced TNF\u2010\u03b1, IFN\u2010\u03b3, IL\u201017A, iNOS\/COX\u20102 and lymphocyte proliferation. These changes were associated with a significant decrease in NF\u2010\u03baB p65 expression and activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HAO472 has positive effects on TNBS\u2010induced colitis by modulating the subsets and functions of lymphocytes, suppressing inflammation and inhibiting the nuclear translocation of NF\u2010\u03baB p65 subunits.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12314","type":"journal-article","created":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T06:14:43Z","timestamp":1451542483000},"page":"104-112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Oridonin derivative ameliorates experimental colitis by inhibiting activated T\u2010cells and translocation of nuclear factor\u2010kappa B"],"prefix":"10.1111","volume":"17","author":[{"given":"Qian Qian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of 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