{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:52:23Z","timestamp":1761630743923},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T00:00:00Z","timestamp":1461801600000},"content-version":"vor","delay-in-days":58,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To establish a non\u2010invasive model for the assessment of portal venous pressure (PVP) based on the magnetic resonance (MR) parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective study, contrast\u2010enhanced magnetic resonance imaging (MRI) scan was performed in 109 patients indicated for upper abdominal surgeries after their written consents were obtained, and intraoperative PVP measurements were completed in 92 patients. Altogether 17 patients were excluded for not undergoing surgery or unsuccessful catheterization. A linear model was constructed for estimating PVP levels in 56 patients and further validation was conducted in the other 36 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PVP levels were significantly correlated with MR parameters, including splenic volume (SV), splenic venous diameter (SVD), liver\/splenic volume ratio, portal venous diameter, hepatic diameter, portal venous cross\u2010sectional area, ascites, varices and arterial portal shunts. A linear model was established as follows: PVP (mmHg) = 2.529 + 1.572 \u00d7 SVD (mm) + 0.231 \u00d7 SV\/body mass index (\u00d7 10<jats:sup>4<\/jats:sup> cm<jats:sup>5<\/jats:sup>\/kg) + 3.44\u2009\u00d7\u2009aspartate aminotransferase\u2010to\u2010platelet ratio index. This model showed excellent accuracy in the detection of portal hypertension, with the area under the receiver operating characteristic curve (AUROC) of 0.945 (95% CI 0.867\u20131.000), with the sensitivity and specificity of 91.7% and 93.7%, respectively. The agreement analysis revealed that the predictive value using this formula closely reflected the patients\u2019 actual PVP level. Moreover, the validation confirmed the accuracy of this model for the assessment of portal hypertension [AUROC 0.935 (95% CI 0.856\u20131.000)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The MRI\u2010based formula has great potential for detecting portal hypertension. As a non\u2010invasive measurement, it may be clinically accepted for the replacement of invasive modalities after further refinement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12325","type":"journal-article","created":{"date-parts":[[2016,2,10]],"date-time":"2016-02-10T09:55:23Z","timestamp":1455098123000},"page":"175-185","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A non\u2010invasive magnetic resonance imaging\u2010based model predicts portal venous pressure"],"prefix":"10.1111","volume":"17","author":[{"given":"Qian Wen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General 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