{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T11:06:52Z","timestamp":1772276812354,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T00:00:00Z","timestamp":1479859200000},"content-version":"vor","delay-in-days":83,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["4625\/B\/P01\/2010\/39"],"award-info":[{"award-number":["4625\/B\/P01\/2010\/39"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to identify the best method of omeprazole (OME) application with respect to intragastric pH, cytochrome P450 2C19 (CYP2C19) genotype and phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The patients with non\u2010variceal upper gastrointestinal bleeding (NVUGIB) were prospectively enrolled. After the achievement of endoscopic hemostasis, the patients were randomized to 40\u2010mg intravenous (<jats:italic>i.v.<\/jats:italic>) OME bolus injection every 12\u2009h or 8\u2010mg\/h continuous <jats:italic>i.v.<\/jats:italic> infusion for 72\u2009h after an 80\u2010mg <jats:italic>i.v.<\/jats:italic> OME bolus administration. The intragastric pH was recorded for 72\u2009h. The CYP2C19 variant alleles (*2, *3, *17) were analyzed and the serum concentrations of OME and 5\u2010hydroxyomeprazole (5\u2010OH OME) were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Altogether 41 Caucasians (18 in the OME infusion [OI] group and 23 in the OME bolus [OB] group) were analyzed. The median percentage of time with an intragastric pH &gt; 4.0 was higher in the infusion group than in the OB group over 48\u2009h (100% <jats:italic>vs<\/jats:italic> 96.6%, <jats:italic>P<\/jats:italic> = 0.009) and 72\u2009h (100% <jats:italic>vs<\/jats:italic> 87.6%, <jats:italic>P<\/jats:italic> = 0.006), and that at an intragastric pH &gt;6.0 was higher in the OI group than the OB group over 72\u2009h (97.9% <jats:italic>vs<\/jats:italic> 63.5%, <jats:italic>P<\/jats:italic> = 0.04). <jats:italic>Helicobacter pylori<\/jats:italic> infection was correlated with the fastest increase in intragastric pH, especially in the OI group. In both groups, CYP2C19 genotypes (*1\/*1, *1\/*17, *17\/*17) had no essential effect on intragastric pH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with NVUGIB, OME <jats:italic>i.v.<\/jats:italic> bolus followed by continuous infusion is more effective than OME <jats:italic>i.v.<\/jats:italic> bolus every 12\u2009h in maintaining higher intragastric pH, regardless of CYP2C19 genetic polymorphisms. <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> infection accelerates the initial elevation of intragastric pH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12393","type":"journal-article","created":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T16:39:01Z","timestamp":1471019941000},"page":"588-599","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of different omeprazole dosing on gastric pH in non\u2010variceal upper gastrointestinal bleeding: A randomized prospective study"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7171-7912","authenticated-orcid":false,"given":"Adam","family":"Chwiesko","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Internal Medicine Medical University of Bialystok  Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radoslaw","family":"Charkiewicz","sequence":"additional","affiliation":[{"name":"Department of Clinical Molecular Biology Medical University of Bialystok  Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Niklinski","sequence":"additional","affiliation":[{"name":"Department of Clinical Molecular Biology Medical University of Bialystok  Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Luczaj","sequence":"additional","affiliation":[{"name":"Department of Inorganic and Analytical Chemistry Medical University of Bialystok  Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elzbieta","family":"Skrzydlewska","sequence":"additional","affiliation":[{"name":"Department of Inorganic and Analytical Chemistry Medical University of Bialystok  Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6241-8283","authenticated-orcid":false,"given":"Robert","family":"Milewski","sequence":"additional","affiliation":[{"name":"Department of Statistics and Medical Informatics Medical University of Bialystok  Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Baniukiewicz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Internal Medicine Medical University of Bialystok  Bialystok 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