{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:33:51Z","timestamp":1791977631835,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T00:00:00Z","timestamp":1484524800000},"content-version":"vor","delay-in-days":76,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the efficacy of Gaviscon Double Action (DA) alginate antacid chewable tablets for reducing esophageal acid exposure in Chinese patients with gastroesophageal reflux disease (GERD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Altogether 44 patients reporting moderate to severe heartburn symptoms underwent two pH monitoring visits. The treatment sequence was randomized to patients received DA alginate antacid or placebo at one visit and the alternate treatment 7 days later. After a standardized reflux\u2010provoking meal, patients took four tablets of DA alginate antacid or placebo. Esophageal pH was measured for 4 h post\u2010dosing using an electrode positioned 5 cm above the lower esophageal sphincter. The primary end\u2010point was the percentage of 4\u2010h post\u2010dosing period with pH &lt;4. Secondary end\u2010points were number of acid reflux episodes (pH &lt;4), longest reflux time and DeMeester scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 44 patients completed the study and provided data for analysis. With DA alginate antacid, the mean percentage time with pH &lt;4 was 5.1%, significantly less (<jats:italic>P<\/jats:italic> = 0.0003) than with placebo (14.8%). DA alginate antacid was statistically significantly superior (<jats:italic>P<\/jats:italic> = 0.0290) to placebo (from at least twofold to threefold better) for all other end\u2010points. Two patients reported two mild adverse events (AEs) that resolved within a month of completing the study. No patients had serious and\/or severe AEs and none withdrew due to AEs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DA alginate antacid was statistically significantly superior to placebo in reducing post\u2010prandial acid exposure without serious clinically relevant health risks. These findings suggest DA alginate antacid tablets are appropriate for treating acid reflux in Chinese GERD patients with heartburn symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12406","type":"journal-article","created":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T23:32:41Z","timestamp":1473809561000},"page":"725-734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Alginate antacid (Gaviscon DA) chewable tablets reduce esophageal acid exposure in Chinese patients with gastroesophageal reflux disease and heartburn symptoms"],"prefix":"10.1111","volume":"17","author":[{"given":"Yao Zong","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Ruijin Hospital, Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing Yuan","family":"Fang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo Wu","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Changhai Hospital, Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Levinson","sequence":"additional","affiliation":[{"name":"Reckitt Benckiser  Hull United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartosz","family":"Jenner","sequence":"additional","affiliation":[{"name":"Reckitt Benckiser  Hull United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Reckitt Benckiser  Hull United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2011.17.3.245"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-7-90"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03671.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2007.00650.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.161927"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.27997"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.178061"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.109421"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.132"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/03639040903388290"},{"key":"e_1_2_6_12_1","first-page":"45","article-title":"Anti\u2010reflux agents: stratification or floatation?","volume":"2","author":"Moss HA","year":"1990","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"4","key":"e_1_2_6_13_1","first-page":"73","article-title":"Gastric residence of Gaviscon Advance and Liquid Gaviscon in healthy volunteers","volume":"49","author":"Taylor G","year":"1997","journal-title":"J Pharm Pharmacol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04678.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.04.046"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12318"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12857"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/030006058000800411"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9284-0"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323001003800208"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1368-5031.2006.00800.x"},{"key":"e_1_2_6_22_1","first-page":"325","article-title":"Twenty\u2010four\u2010hour pH monitoring of the distal esophagus. 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