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Both inpatient and outpatient records were collected and comprehensively reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Altogether 534 <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients were included. The positivity rate of <jats:styled-content style=\"fixed-case\">T\u2010SPOT<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> was 18.0% overall, 31.9% in <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> unclassified, 22.5% in ulcerative colitis and 13.0% in Crohn's disease patients, respectively. Age, history of <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> and the administration of immunosuppressants were significantly associated with <jats:styled-content style=\"fixed-case\">T\u2010SPOT<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> positivity. Among 123 patients who underwent serial testing, the conversion and reversion rate of <jats:styled-content style=\"fixed-case\">T\u2010SPOT.TB<\/jats:styled-content> was 10.2% and 42.9%, respectively. Furthermore, 102 of 447 (22.8%) patients who underwent chest computed tomography (<jats:styled-content style=\"fixed-case\">CT)<\/jats:styled-content> were found with abnormal <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> findings suggestive of <jats:styled-content style=\"fixed-case\">LTBI<\/jats:styled-content>. The concordance rate was 75% between the <jats:styled-content style=\"fixed-case\">T\u2010SPOT.TB<\/jats:styled-content> and chest <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> with a kappa value of 0.25 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.15\u20130.35).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of <jats:styled-content style=\"fixed-case\">LTBI<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients is high in China. Chest <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> is recommended as an alternative to IGRA for screening <jats:styled-content style=\"fixed-case\">LTBI<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients before commencing immunosuppressive therapy in high\u2010prevalence regions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12437","type":"journal-article","created":{"date-parts":[[2016,12,25]],"date-time":"2016-12-25T02:43:52Z","timestamp":1482633832000},"page":"23-30","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Tuberculosis screening using <scp>IGRA<\/scp> and chest computed tomography in patients with inflammatory bowel disease: A retrospective study"],"prefix":"10.1111","volume":"18","author":[{"given":"Dong Juan","family":"Song","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Inflammatory Bowel Disease Research Center, Renji Hospital, School of Medicine Shanghai Jiaotong University, Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Lu","family":"Tong","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Inflammatory Bowel Disease Research Center, Renji Hospital, School of Medicine Shanghai Jiaotong University, Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang Chen","family":"Peng","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Inflammatory Bowel Disease Research Center, Renji Hospital, School of Medicine Shanghai Jiaotong University, Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen Wen","family":"Cai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Inflammatory Bowel Disease Research Center, Renji Hospital, School of Medicine Shanghai Jiaotong University, Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi Tao","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Inflammatory Bowel Disease Research Center, Renji Hospital, School of Medicine Shanghai Jiaotong University, Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming Ming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Inflammatory Bowel Disease Research Center, Renji Hospital, School of Medicine Shanghai Jiaotong University, Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi Hua","family":"Ran","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Inflammatory Bowel Disease Research Center, Renji Hospital, School of Medicine Shanghai Jiaotong University, Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Inflammatory Bowel Disease Research Center, Renji Hospital, School of Medicine Shanghai Jiaotong University, Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.10.001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2016.14.2.111"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2011.02344.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.12.013"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1405427"},{"key":"e_1_2_6_7_1","first-page":"237","article-title":"WHO global tuberculosis control report 2010. 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