{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:13:19Z","timestamp":1788322399148,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T00:00:00Z","timestamp":1501113600000},"content-version":"vor","delay-in-days":56,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>Gastric cardiac carcinoma (GCC) was and is considered as a part of esophageal adenocarcinoma (EAC) and staged with the rules for EAC. This may change. Recent comprehensive integrated genomic investigations on gastric and esophageal carcinomas discovered similar chromosomal instability profiles in these two groups of carcinomas with a gradual increasing gradient from the lowest percentage in the distal gastric antrum to a high level in the proximal gastric cardia, and to the peak of almost 100% in EAC. Therefore, most GCCs and EAC share similar chromosomal instable features of gastric carcinoma and should be grouped as a single disease entity because EAC may be the proximal extension of chromosomal instable GCCs. This breakthrough discovery in genomic characteristics of GCC and EAC would dramatically change the strategy on how patients should be appropriately managed clinically and also greatly help future investigation on detailed molecular pathogenetic mechanisms of GCC, leading to cure this fatal cancer.<\/jats:p>","DOI":"10.1111\/1751-2980.12484","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T09:34:52Z","timestamp":1494927292000},"page":"319-322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Single disease entity for both chromosomal instable subtype gastric adenocarcinoma and esophageal adenocarcinoma"],"prefix":"10.1111","volume":"18","author":[{"given":"Qin","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pathology Nanjing Drum Tower Hospital  Nanjing China"},{"name":"Changzhou Second Hospital  Changzhou Jiangsu Province China"},{"name":"Department of Pathology and Laboratory Medicine, Boston Brigham and Women's Hospital Veterans Affairs Boston Healthcare System, and Harvard Medical School  West Roxbury MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,27]]},"reference":[{"key":"e_1_2_2_2_1","volume-title":"GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11","author":"Ferlay J","year":"2013"},{"key":"e_1_2_2_3_1","first-page":"10","article-title":"Report of incidence and mortality in China cancer registries, 2009","volume":"25","author":"Chen W","year":"2013","journal-title":"Chin J Cancer Res"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12355"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-016-0601-9"},{"key":"e_1_2_2_6_1","first-page":"129","volume-title":"AJCC Cancer Staging Manual","author":"American Joint Committee on Cancer Staging Manual","year":"2009"},{"key":"e_1_2_2_7_1","first-page":"203","volume-title":"AJCC Cancer Staging Manual","author":"American Joint Committee on Cancer","year":"2017"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13480"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20805"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03924.x"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-014-0402-y"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.183"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182294764"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31824beb95"}],"container-title":["Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1751-2980.12484","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-2980.12484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T01:16:49Z","timestamp":1696295809000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1751-2980.12484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/1751-2980.12484"],"URL":"https:\/\/doi.org\/10.1111\/1751-2980.12484","archive":["Portico"],"relation":{},"ISSN":["1751-2972","1751-2980"],"issn-type":[{"value":"1751-2972","type":"print"},{"value":"1751-2980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"2017-05-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}