{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:57:15Z","timestamp":1789811835734,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Kaohsiung Medical University Aim for the Top Universities","award":["KMU-TP105-G00"],"award-info":[{"award-number":["KMU-TP105-G00"]}]},{"name":"Kaohsiung Medical University Aim for the Top Universities","award":["KMU-TP105G01"],"award-info":[{"award-number":["KMU-TP105G01"]}]},{"name":"Kaohsiung Medical University Aim for the Top Universities","award":["103-CCH-KMU-002"],"award-info":[{"award-number":["103-CCH-KMU-002"]}]},{"DOI":"10.13039\/501100004738","name":"E-Da Hospital","doi-asserted-by":"crossref","award":["EDAHP103044"],"award-info":[{"award-number":["EDAHP103044"]}],"id":[{"id":"10.13039\/501100004738","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>This was a prospective study aiming to investigate whether levofloxacin plus bismuth\u2010based quadruple therapy was more effective than levofloxacin\u2010based triple therapy after failed first\u2010line eradication therapies for <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Sixty\u2010seven patients infected with <jats:italic>H. pylori<\/jats:italic> were randomly assigned to two groups; the levofloxacin plus bismuth\u2010based quadruple therapy group (RBAL [<jats:italic>n<\/jats:italic> = 33]; rabeprazole 20 mg twice daily, bismuth subcitrate 120 mg four times daily, amoxicillin 1 g twice daily and levofloxacin 500 mg once daily, for 10 days) and the levofloxacin\u2010based triple therapy group (RAL [<jats:italic>n<\/jats:italic> = 34]; rabeprazole 20 mg twice daily, amoxicillin 1 g twice daily and levofloxacin 500 mg once daily, for 10 days). Endoscopy was performed 4\u20138 weeks after <jats:italic>H. pylori<\/jats:italic> eradication to assess treatment response. We followed up patient response and compliance and checked their resistance to antibiotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Intention\u2010to\u2010treat analysis revealed that both groups had similar eradication rates (RBAL <jats:italic>vs<\/jats:italic> RAL: 84.8% [95% confidence interval {CI} 72.6\u201397.1%] <jats:italic>vs<\/jats:italic> 67.6% [95% CI 51.9\u201383.4%], <jats:italic>P<\/jats:italic> = 0.0987). No significant differences in compliance or adverse events were found (<jats:italic>P<\/jats:italic> = 0.9829 and 0.0720). Epsilometer test showed that most eradication failure cases were levofloxacin\u2010resistant.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Adding bismuth subcitrate to levofloxacin\u2010based triple therapy was not more effective than not doing so, but no further side effects were noted. Both eradication therapies were equally safe and patients had the same tolerance to both regimens. Resistance rate to levofloxacin may be important when choosing second\u2010line therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12498","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T21:53:14Z","timestamp":1498254794000},"page":"537-542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Comparison of 10\u2010day levofloxacin bismuth\u2010based quadruple therapy and levofloxacin\u2010based triple therapy for <i>Helicobacter pylori<\/i>"],"prefix":"10.1111","volume":"18","author":[{"given":"Tzung\u2010Shiun","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan China"},{"name":"Department of Internal Medicine Pingtung Hospital, Ministry of Health and Welfare  Pingtung Taiwan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping\u2010I","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Kaohsiung Veterans\u2019 General Hospital and National Yangming University  Kaohsiung Taiwan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Hung","family":"Kuo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan China"},{"name":"Faculty of Medicine, Department of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan China"},{"name":"Center for Stem Cell Research Kaohsiung Medical University  Kaohsiung Taiwan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang\u2010Ming","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan China"},{"name":"Faculty of Medicine, Department of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u2010Chen","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan China"},{"name":"Faculty of Medicine, Department of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie S.W.","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Wen","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Changhua Christian Hospital  Changhua Taiwan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010Chen","family":"Kuo","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine E\u2010Da Hospital, I\u2010Shou University  Kaohsiung Taiwan 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