{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:32:12Z","timestamp":1784896332713,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T00:00:00Z","timestamp":1513900800000},"content-version":"vor","delay-in-days":51,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Esophagogastroduodenoscopy (EGD) is a standard instrument for detecting upper gastrointestinal lesions. However, the distal duodenum is often missed. This study aimed to clarify the diagnostic role of EGD in the distal duodenum.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This retrospective study enrolled patients with distal duodenal lesions who underwent EGD between January 2004 and July 2016 at our center. The rate of missed diagnosis using EGD examination was calculated. Logistic regression analysis was performed to identify the factors associated with the missed diagnoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Sixty\u2010three patients were included in the study. The overall diagnostic rate of distal duodenal lesions on EGD was 58.7%. After excluding the patients in whom the EGD did not reach the distal duodenum, this rate rose to 82.2%. In univariate analysis, intravenous sedation (26.8% <jats:italic>vs<\/jats:italic> 68.2%, odds ratio [OR] 0.171, <jats:italic>P<\/jats:italic> = 0.002), signs of lesions adjacent to the stomach (19.4% <jats:italic>vs<\/jats:italic> 62.5%, OR 0.099, <jats:italic>P<\/jats:italic> = 0.001), prior enteroscopy experience (15.0% <jats:italic>vs<\/jats:italic> 87.0%, OR 0.026, <jats:italic>P<\/jats:italic> &lt; 0.001), and endoscopists with experiences of over 10 years (13.8% <jats:italic>vs<\/jats:italic> 64.7%, OR 0.087, <jats:italic>P<\/jats:italic> = 0.000) were associated with a decreased risk of missed diagnosis. In multivariate analysis, signs of lesions adjacent to the stomach (OR 0.167, <jats:italic>P<\/jats:italic> = 0.039) and prior enteroscopy experience (OR 0.035, <jats:italic>P<\/jats:italic> &lt; 0.001) were significant independent protective factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>EGD may be important in diagnosing distal duodenal lesions. Patients with gastric retention, blood in the stomach or erosion in the proximal duodenum may benefit from the deep insertion of EGD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12549","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T13:52:41Z","timestamp":1507816361000},"page":"618-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Role of esophagogastroduodenoscopy in detecting distal duodenal lesions: A single\u2010center pilot study in Southern China"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8423-0724","authenticated-orcid":false,"given":"Wei Guang","family":"Qiao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Guangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province Nanfang Hospital, Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze Min","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Guangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province Nanfang Hospital, Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Tang","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Beijing Tsinghua Changgung Hospital, Medical Center, Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong Yin","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Guangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province Nanfang Hospital, Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Xin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Guangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province Nanfang Hospital, Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"De Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Guangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province Nanfang Hospital, Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1495-3043","authenticated-orcid":false,"given":"Fa Chao","family":"Zhi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Guangdong Provincial Key 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