{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:13:41Z","timestamp":1740147221907,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T00:00:00Z","timestamp":1513900800000},"content-version":"vor","delay-in-days":51,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Shanghai Outstanding Medical Academic Leader Program","award":["2015-83"],"award-info":[{"award-number":["2015-83"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Endoscopic management of malignant hilar biliary obstruction (MHBO) remains challenging, with relatively poor jaundice control and high infectious risk. The factors that affect the outcome of endoscopic therapy are still unclear. This retrospective cohort study aimed to investigate predictive factors for the outcomes of biliary stenting in patients with MHBO.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Between June 2015 and June 2016, consecutive patients with MHBO who received primary endoscopic stenting and completed follow\u2010up at our institution were identified and evaluated. All patients received full aspiration of congested bile followed by plastic or metal stent(s) placement. Clinical success was achieved in patients whose total serum bilirubin decreased by over two\u2010thirds in a month.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 64 patients were included. Among them, 28 received a single stent placement and 36 received multiple stent placements. Altogether 53 (82.8%) patients attained clinical success and 48 (75.0%) underwent re\u2010interventions within 6 months. Multivariate analyses showed that only a total bile volume of \u226530 mL aspirated from the intrahepatic ducts predicted clinical success (OR 6.83, 95% CI 1.2\u201338.4, <jats:italic>P<\/jats:italic> = 0.029), absence of early post\u2010endoscopic retrograde cholangiopancreatography cholangitis (OR 0.03, 95% CI 0.004\u20130.36, <jats:italic>P<\/jats:italic> = 0.001), and lack of re\u2010intervention within 6 months (HR 0.10, 95% CI 0.05\u20130.22, <jats:italic>P<\/jats:italic> &lt; 0.001) after initial endoscopic stenting.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The volume of congested bile may effectively predict treatment outcomes of endoscopic stenting for MHBO and guide the therapeutic strategy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12555","type":"journal-article","created":{"date-parts":[[2017,10,28]],"date-time":"2017-10-28T02:12:40Z","timestamp":1509156760000},"page":"650-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Congested bile can predict the outcomes of endoscopic stenting for hilar biliary malignancies"],"prefix":"10.1111","volume":"18","author":[{"given":"Ming Xing","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Gastroenterology &amp; Endoscopy, Eastern Hepatobiliary Hospital Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Endoscopy, Eastern Hepatobiliary Hospital Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Endoscopy, Eastern Hepatobiliary Hospital Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6365-7841","authenticated-orcid":false,"given":"Dao Jian","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Endoscopy, Eastern Hepatobiliary Hospital Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Endoscopy, Eastern Hepatobiliary Hospital Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Endoscopy, Eastern Hepatobiliary Hospital Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian Tian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Endoscopy, Eastern Hepatobiliary Hospital Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4167-9083","authenticated-orcid":false,"given":"Bing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Endoscopy, Eastern Hepatobiliary Hospital Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01645.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2012.12.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12092"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2014.47.5.440"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.512"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.113381"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2010.01036.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328360b9ec"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.10.013"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-102651"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2178-4"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.06.040"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.04.046"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-011-0383-0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.116900"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2006.12.025"},{"key":"e_1_2_6_18_1","first-page":"91","article-title":"Clinical significance of white bile (bilirubin\u2010free bile) in malignant bile duct obstruction","volume":"52","author":"Jung JT","year":"2008","journal-title":"Korean J Gastroenterol"}],"container-title":["Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1751-2980.12555","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-2980.12555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T11:57:06Z","timestamp":1695988626000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1751-2980.12555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/1751-2980.12555"],"URL":"https:\/\/doi.org\/10.1111\/1751-2980.12555","archive":["Portico"],"relation":{},"ISSN":["1751-2972","1751-2980"],"issn-type":[{"type":"print","value":"1751-2972"},{"type":"electronic","value":"1751-2980"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"2017-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}