{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:13:53Z","timestamp":1740147233690,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T00:00:00Z","timestamp":1530576000000},"content-version":"vor","delay-in-days":32,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007162","name":"Guangdong Science and Technology Department","doi-asserted-by":"publisher","award":["2014A020212128","2016A020214006"],"award-info":[{"award-number":["2014A020212128","2016A020214006"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270473","81470821","81600408","81630018"],"award-info":[{"award-number":["81270473","81470821","81600408","81630018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To investigate the role of heat shock protein family A member 6 (HSPA6) expression alone and in combination with clinical characteristics in distinguishing intestinal Beh\u00e7et\u2019s disease (BD) from Crohn\u2019s disease (CD) with ileocolonic involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Patients diagnosed with either intestinal BD or CD were enrolled. Their clinical characteristics, disease activity, laboratory test results including hypersensitive C\u2010reactive protein (hsCRP) and erythrocyte sedimentation rate (ESR), endoscopic, pathological and radiological features were retrospectively analyzed. Enzyme\u2010linked immunosorbent assay was applied to measure serum HSPA6 levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Among intestinal BD patients, abdominal pain and diarrhea were the leading gastrointestinal symptoms. Submucosal lymphocyte infiltration was the most common pathological finding. Computed tomography enterography features involved number of segments of less than 4 and bowel wall thickening. Independent factors were round\/ellipsoid intestinal ulcer (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), number of ulcers\u2009\u22645 (<jats:italic>P<\/jats:italic>\u2009=\u20090.050), elevated ulcer margin (<jats:italic>P<\/jats:italic>\u2009=\u20090.019), absence of aphthous ulcer (<jats:italic>P<\/jats:italic> = 0.005), bowel wall thickening &gt;13\u2009mm (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and serum HSPA6 level &gt;3.725 ng\/mL (<jats:italic>P<\/jats:italic> = 0.008) for the differential diagnosis between intestinal BD and CD. Serum HSPA6 expression was significantly elevated in intestinal BD (0.72\u2009\u00b1\u20090.39\u2009ng\/mL) compared with CD (0.50\u2009\u00b1\u20090.24\u2009ng\/mL, <jats:italic>P<\/jats:italic>\u2009=\u20090.000) and healthy controls (0.38\u2009\u00b1\u20090.37\u2009ng\/mL, <jats:italic>P<\/jats:italic>\u2009=\u20090.000).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>HSPA6 in combination with clinical, radiological and pathological characteristics is useful in distinguishing intestinal BD from CD with ileocolonic involvement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12613","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T06:19:12Z","timestamp":1527747552000},"page":"350-358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Heat shock protein family A member 6 combined with clinical characteristics for the differential diagnosis of intestinal Beh\u00e7et\u2019s disease"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4173-2147","authenticated-orcid":false,"given":"Rui","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiology First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bai Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong Province 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