{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:55:00Z","timestamp":1780084500530,"version":"3.54.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T00:00:00Z","timestamp":1536451200000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701746"],"award-info":[{"award-number":["81701746"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81302092"],"award-info":[{"award-number":["81302092"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To investigate the relationship between creeping fat and inflammatory activity as well as the prognosis of ileo\u2010colonic Crohn's disease (CD), based on a quantitative analysis of energy spectral computed tomography (CT).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A total of 40 patients with CD and 40 with other gastrointestinal diseases who underwent an energy spectral CT scanning between March 2014 and March 2015 were retrospectively enrolled. The endoscopic severity of CD was evaluated by the simple endoscopic score for Crohn's disease (SES\u2010CD). The slope of the Hounsfield unit (HU) curve (\u03bb<jats:sub>HU<\/jats:sub>) was measured and calculated on energy spectral CT images. Visceral and subcutaneous fat areas were also measured. The relationship between the quantitative data of creeping fat as well as the fat area and CD inflammation were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The \u03bb<jats:sub>HU<\/jats:sub> of creeping fat in patients with CD increased with the severity of intestinal inflammation (moderate\/severe <jats:italic>vs<\/jats:italic> mild: \u22120.17\u2009\u00b1\u2009\u22120.68 <jats:italic>vs<\/jats:italic>\u2009\u22120.49\u2009\u00b1\u2009\u22120.61, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Moreover, the \u03bb<jats:sub>HU<\/jats:sub> of creeping fat around the intestinal segments without lesions in CD was significantly larger than that in the controls (\u22121.19\u2009\u00b1\u2009\u22120.56 <jats:italic>vs<\/jats:italic>\u2009\u2212\u20091.42\u2009\u00b1\u2009\u22120.45, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The \u03bb<jats:sub>HU<\/jats:sub> was more accurate for detecting inflammatory lesions in CD than for calculating visceral fat. It was significantly correlated with SES\u2010CD (<jats:italic>r<\/jats:italic>\u2009=\u20090.66, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and moderately correlated with the Harvey\u2013Bradshaw index (<jats:italic>r<\/jats:italic>\u2009= 0.414, <jats:italic>P<\/jats:italic> &lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The quantitative analysis of creeping fat using energy spectral CT is an effective method in inflammatory evaluation in patients with CD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12652","type":"journal-article","created":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T05:10:00Z","timestamp":1533013800000},"page":"475-484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Creeping fat in patients with ileo\u2010colonic Crohn's disease correlates with disease activity and severity of inflammation: A preliminary study using energy spectral computed tomography"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9518-0355","authenticated-orcid":false,"given":"Qi","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Radiology Renji Hospital, School of Medicine, Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi Tao","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health Inflammatory Bowel Disease Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health Inflammatory Bowel Disease Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Qi","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Radiology Renji Hospital, School of Medicine, Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi Hua","family":"Ran","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health Inflammatory Bowel Disease Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology Renji Hospital, School of Medicine, Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(52)90025-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.061531"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300391"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.08.018"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(200002)190:2<196::AID-PATH513>3.0.CO;2-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000503"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000527"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13128"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2016150185"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X16668309"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21048"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(04)01878-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.167957"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000114"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.082925"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200606000-00005"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20937"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01537.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.084301"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2014.12.1.42"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000978"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.05.005"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000200"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.334125074"},{"key":"e_1_2_6_26_1","first-page":"293","article-title":"Main imaging features of Crohn's disease: agreement between MR\u2010enterography and CT\u2010enterography","volume":"17","author":"Amitai MM","year":"2015","journal-title":"Isr Med Assoc J"}],"container-title":["Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1751-2980.12652","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-2980.12652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T23:14:44Z","timestamp":1694992484000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1751-2980.12652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/1751-2980.12652"],"URL":"https:\/\/doi.org\/10.1111\/1751-2980.12652","archive":["Portico"],"relation":{},"ISSN":["1751-2972","1751-2980"],"issn-type":[{"value":"1751-2972","type":"print"},{"value":"1751-2980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"2018-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}