{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:22:37Z","timestamp":1774527757533,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National High Technology Research and Development Program of China","award":["2010AA023007"],"award-info":[{"award-number":["2010AA023007"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the effects of different test meals on esophageal and intragastric pH in patients with gastroesophageal reflux disease (GERD) and healthy subjects and to demonstrate the relationship between esophageal acid exposure (EAE) and gastric pH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled patients with reflux esophagitis (RE; <jats:italic>n<\/jats:italic>\u2009=\u200915), nonerosive reflux disease (NERD; <jats:italic>n<\/jats:italic>\u2009=\u200912) and healthy subjects (<jats:italic>n<\/jats:italic>\u2009=\u200910). Four pH electrodes were used to monitor the pH of the distal esophagus, upper border of the lower esophageal sphincter, gastric fundus, and gastric body for 26\u2009hours. Isocaloric and isovolumetric high\u2010fat, standard, and functional meals were supplied randomly to the participants. The EAE and gastric acidity of each meal in fasting and postprandial states were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High\u2010fat meals significantly increased postprandial EAE in patients with RE and NERD. EAE was higher after a high\u2010fat meal than after a standard or functional food meals at the fourth hour postprandially in patients with RE (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Patients with NERD reported fewer symptoms after a functional food meal than after high\u2010fat and standard meals (0 [interquartile range {IQR} 0\u20131] <jats:italic>vs<\/jats:italic> 1 [IQR 0\u20132] <jats:italic>vs<\/jats:italic> 3 [IQR 1\u20134], <jats:italic>P<\/jats:italic>\u2009=\u20090.014). Compared with high\u2010fat and standard meals, functional food meal significantly decreased gastric acidity in patients with RE. EAE was significantly related to gastric acidity in patients with RE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High\u2010fat meals increased EAE in patients with RE and NERD. Functional food could serve as adjuvant therapy in GERD patients. EAE was related to gastric acidity in RE patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12676","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T04:23:17Z","timestamp":1538367797000},"page":"664-673","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Effect of high\u2010fat, standard, and functional food meals on esophageal and gastric pH in patients with gastroesophageal reflux disease and healthy subjects"],"prefix":"10.1111","volume":"19","author":[{"given":"Wen Juan","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan Tao","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Hong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Qing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Guo","sequence":"additional","affiliation":[{"name":"Beijing Wei Di Kang Tai Medical Equipment Ltd.  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li Ming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Tongrentang Health Pharmaceutical Co., Ltd.  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