{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T19:07:46Z","timestamp":1761419266287,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Autoimmune pancreatitis is an autoimmune disorder accompanied by clinicopathological manifestations that have been established as immunoglobulin (IgG)4\u2010related diseases (IgG4\u2010RD). Other IgG4\u2010RD are often involved with autoimmune pancreatitis. They sometimes relapse despite a favorable response to steroid therapy. This study aimed to clarify the patterns and risk factors for extrapancreatic relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the data of 115 patients diagnosed with definite autoimmune pancreatitis type 1 and followed up for &gt;\u20091 year. We analyzed two items: the timing and pattern of extrapancreatic relapse, and risk factors for relapse with three common manifestations: IgG4\u2010related sclerosing cholangitis (SC), IgG4\u2010related dacryoadenitis and sialadenitis (DS), and IgG4\u2010related retroperitoneal fibrosis (RF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Remission was achieved in all patients, except one. The extrapancreatic relapse rates were 11.0%, 19.7%, and 40% within 3, 5, and 10 years, respectively. Of 26 patients with extrapancreatic relapse, nine (34.6%) relapsed with a new IgG4\u2010RD. Based on multivariate analysis, the interval between symptom onset and steroid initiation, and the presence of RF at onset were significant risk factors for relapse with SC and RF, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that they may be various extrapancreatic relapse patterns especially in autoimmune pancreatitis with other organ involvement. Patients with a delayed initiation of steroids or RF at onset should be carefully followed up as high\u2010risk groups for SC and RF relapse.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12708","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T08:59:04Z","timestamp":1548925144000},"page":"152-158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Relapse patterns and predictors of IgG4\u2010related diseases involved with autoimmune pancreatitis: A single\u2010center retrospective study of 115 patients"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4896-5157","authenticated-orcid":false,"given":"Masami","family":"Miki","sequence":"first","affiliation":[{"name":"Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences, Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nao","family":"Fujimori","sequence":"additional","affiliation":[{"name":"Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences, Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takamasa","family":"Oono","sequence":"additional","affiliation":[{"name":"Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences, Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Kawabe","sequence":"additional","affiliation":[{"name":"Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences, Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihisa","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences, Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhide","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences, Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhito","family":"Teramatsu","sequence":"additional","affiliation":[{"name":"Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences, Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Tachibana","sequence":"additional","affiliation":[{"name":"Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences, Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences, Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02232341"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02285209"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1175-y"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-011-0571-z"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1908-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39132"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.40"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2014.950036"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3182142fd2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.05.017"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2016.02.006"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-018-1434-6"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1163-7"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12526"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.52.0306"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.172908"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3182480c99"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1302-1"},{"issue":"4","key":"e_1_2_6_20_1","first-page":"432","article-title":"IgG4\u2010related retroperitoneal fibrosis and sclerosing cholangitis independent of autoimmune pancreatitis. 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