{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:12:24Z","timestamp":1782141144208,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,3,10]],"date-time":"2019-03-10T00:00:00Z","timestamp":1552176000000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370500"],"award-info":[{"award-number":["81370500"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770559"],"award-info":[{"award-number":["81770559"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To investigate the performance of the quantitative immunochemical fecal occult blood test (qFIT) and to determine the association between the <jats:styled-content>fecal<\/jats:styled-content> hemoglobin (Hb) level and the location and size of adenomas and the stages of colorectal cancer (CRC).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A total of 692 participants were included in the study. Their fecal Hb level was measured using an OC\u2010SENSA MICRO qFIT. The colonoscopy results, including the location, size, and histological features of the adenomas, as well as the relationship between the Hb level and different characteristics were analyzed. Performance of the qFIT at various thresholds of fecal Hb levels was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Advanced colorectal neoplasia (ACRN) was identified in 76 patients based on the colonoscopic and pathological examinations. Large adenomas (\u226510 mm) had a higher fecal Hb level than small adenomas (&lt;10 mm). Advanced adenomas located on the left side of the colon presented with a higher fecal Hb level than those on the right side (<jats:italic>P<\/jats:italic>\u2009=\u20090.022). Stage III\u2010IV CRC patients had a significantly higher Hb level than stage I\u2010II patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.013). The sensitivity and specificity of qFIT for ACRN was 51.3% and 86.4%\uff0crespectively, with the best cut\u2010off level of 400\u2009ng\/mL. The sensitivity and specificity for CRC was 61.0% and 89.1%, with the best cut\u2010off level of 500\u2009ng\/mL.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>qFIT has an acceptable sensitivity and specificity for ACRN detection. Furthermore, the qFIT results are associated with the location and size of adenomas as well as the grade of CRC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12711","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T04:38:01Z","timestamp":1549255081000},"page":"78-82","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Quantitative immunochemical fecal occult blood test for neoplasia in colon cancer screening"],"prefix":"10.1111","volume":"20","author":[{"given":"Si Yi","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Fu","sequence":"additional","affiliation":[{"name":"Medical Examination Center, Panjinliaoyou Gem Flower Hospital  Panjin Liaoning Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Xuan","family":"Lang","sequence":"additional","affiliation":[{"name":"The Fourth Hospital of Jilin University (FAW General Hospital)  Changchun Jilin Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Chi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncological Surgery, Panjinliaoyou Gem Flower Hospital  Panjin Liaoning Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya Nan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia Ming","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing Nan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011303432203"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g2467"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja14.00197"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.179"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djm150"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.00231.x"},{"issue":"4","key":"e_1_2_7_9_1","first-page":"442","article-title":"Clinical impact of the immunochemical fecal occult blood test for colorectal cancer screening in Brazil","volume":"30","author":"Teixeira CR","year":"2017","journal-title":"Ann 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