{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T01:44:34Z","timestamp":1784684674873,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T00:00:00Z","timestamp":1554163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81402551"],"award-info":[{"award-number":["81402551"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008235","name":"Peking Union Medical College Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008235","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the impact of gastrointestinal manifestations on quality of life in patients with systemic sclerosis (SSc) and to provide clinical evidence for their early treatment and health\u2010related management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Altogether 65 patients admitted to the Peking Union Medical College Hospital selected from a disease cohort and 127 matched controls were enrolled. A self\u2010assessment questionnaire was completed by all participants. Each participant completed scleroderma gastrointestinal tract 1.0 (SSC\u2010GIT 1.0) questionnaire (including reflux or indigestion, diarrhea, constipation, distention, emotional well\u2010being, and social functioning). Autoimmune antibodies were tested in SSc patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among these SSc cases, gastrointestinal manifestations were seen in 84.6%. Reflux\/indigestion and diarrhea were more common in SSc patients than in the control group (67.7% vs 27.8%; 27.7% vs 10.2%, <jats:italic>P<\/jats:italic>\u2009&lt; 0.05). SSc patients had a significantly higher percentage of abnormal social functioning than the control group (33.8% vs 3.9%, <jats:italic>P<\/jats:italic>\u2009&lt; 0.05). SSc patients with abnormal social functioning and abnormal emotional well\u2010being had worse distention, diarrhea, and constipation statuses. Patients with reflux or indigestion and diarrhea had lower anti\u2010Scl\u201070 level than those without (both <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Patients with distention had higher levels of anti\u2010RNP and anti\u2010SSA than those without distention (both <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Patients with diarrhea had higher levels of anti\u2010RNP than those without diarrhea (<jats:italic>P<\/jats:italic>\u2009=\u20090.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gastrointestinal involvement is frequent in SSc, with reflux or indigestion as the most common symptom. The impaired quality of life in patients with SSc indicates that early and active management should be considered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12720","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T07:55:21Z","timestamp":1551858921000},"page":"256-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Gastrointestinal manifestations on impaired quality of life in systemic sclerosis"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2986-7324","authenticated-orcid":false,"given":"Hong","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College Chinese Academy of Medical Sciences  Beijing 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