{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T10:35:26Z","timestamp":1773484526355,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470805"],"award-info":[{"award-number":["81470805"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873554"],"award-info":[{"award-number":["81873554"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study was designed to test whether serum vitamin D levels affected <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) infection and eradication rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter observational prospective cohort study was conducted. A total of 496 <jats:italic>H. pylori<\/jats:italic><jats:sup>\u2212<\/jats:sup> positive (<jats:italic>H. pylori<\/jats:italic><jats:sup>+<\/jats:sup>) and 257 <jats:italic>H. pylori<\/jats:italic>\u2010negative (<jats:italic>H. pylori<\/jats:italic><jats:sup>\u2212<\/jats:sup>) patients were enrolled from four hospitals in China. Baseline serum vitamin D levels were measured and a <jats:sup>13<\/jats:sup>C\u2010urea breath test (UBT) was performed for all the participants. The <jats:italic>H. pylori<\/jats:italic><jats:sup>+<\/jats:sup> patients were divided into two subgroups based on their serum vitamin D levels (&lt;10 or \u226510\u2009ng\/mL). A second <jats:sup>13<\/jats:sup>C\u2010UBT was performed between 4 and 8\u2009weeks after 14\u2010day bismuth\u2010containing quadruple eradication therapies. Factors potentially affecting <jats:italic>H. pylori<\/jats:italic> eradication were determined using a questionnaire survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum vitamin D levels were significantly lower in the <jats:italic>H. pylori<\/jats:italic><jats:sup>+<\/jats:sup> group than in the <jats:italic>H. pylori<\/jats:italic><jats:sup>\u2212<\/jats:sup> group ([17.0\u2009\u00b1\u20096.9] ng\/mL vs [19.2\u2009\u00b1\u20098.0] ng\/mL, <jats:italic>P<\/jats:italic> = 0.000). <jats:italic>H. pylori<\/jats:italic> eradication rate significantly differed between patients with serum vitamin D levels of &lt;10 ng\/mL and \u226510\u2009ng\/mL (71.7% vs 87.3%, <jats:italic>P<\/jats:italic> = 0.005). A multivariate analysis showed that having serum vitamin D level \u226510\u2009ng\/mL was an independent risk factor for a successful <jats:italic>H. pylori<\/jats:italic> eradication (odds ratio 0.381, 95% confidence interval 0.183\u20100.791, <jats:italic>P<\/jats:italic> = 0.010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum vitamin D level may affect <jats:italic>H. pylori<\/jats:italic> infection and its eradication. Randomized controlled trials are needed to find out whether vitamin D supplements may increase the <jats:italic>H. pylori<\/jats:italic> eradication rate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12793","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T15:54:26Z","timestamp":1559231666000},"page":"421-426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Influence of serum vitamin D level on <i>Helicobacter pylori<\/i> eradication: A multi\u2010center, observational, prospective and cohort study"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0330-1082","authenticated-orcid":false,"given":"Chuan","family":"Han","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases Air Force Military Medical University  Xi'an 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Army  Luoyang Henan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases Air Force Military Medical University  Xi'an Shaanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shaanxi Provincial People's Hospital  Xi'an Shaanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xianyang Central Hospital  Xianyang Shaanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han Bing","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of 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