{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T08:52:43Z","timestamp":1768899163100,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The cost of treating the rare eosinophilic esophagitis (EoE) disease and its impact on patients\u2019 quality of life have not been well documented in the literature. This study seeks to fill this gap by comparing the cost of EoE with other well\u2010known inflammatory diseases, including Crohn's disease (CD) and celiac disease (CeD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A Mann\u2010Whitney <jats:italic>U<\/jats:italic> test and multiple logistic regression were used to examine the cost of EoE in the state of Nevada across all hospital settings and its impact on quality of life compared with CD and CeD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Several factors were associated with the overall cost of EoE in Nevada, including patients\u2019 age, sex and region (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). EoE was significantly more expensive to treat in the pediatric group ($4001 EoE; $985 CD; $856 CeD), among men ($2532 EoE; $1500 CD; $1724 CeD), among those residing in the southern region of Nevada ($4501 EoE; $2538 CD; $1888 CeD), and among patients seeking medical care from outpatient clinics ($3298 EoE; $741 CD; $1686 CeD) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Age, sex, region and hospital setting were all associated with having a positive EoE record compared with CeD or CD (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Data from this study indicate that the EoE burden is significantly higher in cost for certain demographics and regions compared with CD and CeD in the state of Nevada, specifically among pediatric and male patients. These differences suggest that clinicians may encounter similar issues when treating EoE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12832","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T10:35:05Z","timestamp":1574418905000},"page":"12-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cost of chronic inflammatory disease: The impact of eosinophilic esophagitis in Nevada"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5582-7206","authenticated-orcid":false,"given":"Julia","family":"Anderson","sequence":"first","affiliation":[{"name":"School of Public Health, University of Nevada Las Vegas  Las Vegas Nevada USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheniz","family":"Moonie","sequence":"additional","affiliation":[{"name":"School of Public Health, University of Nevada Las Vegas  Las Vegas Nevada USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Beth","family":"Hogan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Joan C. Edwards School of Medicine, Marshall University  Huntington West Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Scherr","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Nevada Las Vegas  Las Vegas Nevada USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Labus","sequence":"additional","affiliation":[{"name":"School of Public Health, University of Nevada Las Vegas  Las Vegas Nevada USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Word","sequence":"additional","affiliation":[{"name":"Department of Urban Affairs University of Nevada Las Vegas  Las Vegas Nevada USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-018-8683-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-017-8665-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2017.07.001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.316"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21968"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181a70af4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","unstructured":"StewartMJ ShafferE UrbanskiSJ BeckPL StorrMA.The association between celiac disease and eosinophilic esophagitis in children and adults. 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