{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T06:26:49Z","timestamp":1767162409301,"version":"build-2238731810"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,2,16]],"date-time":"2020-02-16T00:00:00Z","timestamp":1581811200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570551"],"award-info":[{"award-number":["81570551"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770607[Corrections added on 11 May 2020, after first online publication: Copyediting amendments were made throughout the article.]"],"award-info":[{"award-number":["81770607[Corrections added on 11 May 2020, after first online publication: Copyediting amendments were made throughout the article.]"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the effectiveness of gadobenate dimeglumine (Gd\u2010BOPTA)\u2010enhanced magnetic resonance imaging (MRI) in predicting portal hypertension and high\u2010risk esophageal varices (EV) in patients with hepatitis B cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 71 and 30 patients were enrolled in the training and validation groups, respectively. Univariate and multivariate analyses were performed to detect patient's risk of developing high\u2010risk EV to generate a formula for scoring EV. The relationships between the relative enhancement (RE) ratio of Gd\u2010BOPTA\u2010enhanced MRI and portal vein pressure were explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Platelet count, portal vein width and RE were identified as independent predictors of high\u2010risk EV. Based on these parameters, the EV score model were calculated as: \u22126.483\u2009+\u200915.612\u2009\u00d7\u2009portal vein width (cm)\u2009+\u20092.251\u2009\u00d7\u2009RE \u2212 0.176\u2009\u00d7\u2009platelet count (\u00d710\n                      <jats:sup>9<\/jats:sup>\n                      \/L). The area under the receiver operating characteristic curve was 0.903. At a cut\u2010off value of \u2264\u22122.74, the negative predictive value was 94.00%, while the positive predictive value was as high as 93.80% when the cut\u2010off was set at &gt;4.00. Gd\u2010BOPTA\u2010enhanced MRI was effective in predicting portal pressure. Its accuracy was confirmed with the validation set.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Gd\u2010BOPTA\u2010enhanced MRI was successfully applied to evaluate high\u2010risk EV and portal hypertension. These results show that it is an accurate, non\u2010invasive model for detecting high\u2010risk EV, based on which we propose a cost\u2010effective algorithm for EV management, eliminating the need to perform an endoscopy in all patients with cirrhosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1751-2980.12843","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T15:12:52Z","timestamp":1578669172000},"page":"104-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Gadobenate dimeglumine\u2010enhanced magnetic resonance imaging can accurately predict the severity of esophageal varices and portal vein pressure in patients with hepatitis B cirrhosis"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7203-5358","authenticated-orcid":false,"given":"Qian","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Shandong Provincial Hospital affiliated to Shandong University  Jinan Shandong Province, China"},{"name":"Department of Gastroenterology Liaocheng People\u2019s Hospital  Liaocheng Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Hepatology Liaocheng People\u2019s Hospital  Liaocheng Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing Run","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Liaocheng People\u2019s Hospital  Liaocheng Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin Ya","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology Shandong Provincial Hospital affiliated to Shandong University  Jinan Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan Chen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Liaocheng People\u2019s Hospital  Liaocheng Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shandong Provincial Hospital affiliated to Shandong University  Jinan Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue Min","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shandong Provincial Hospital affiliated to Shandong University  Jinan Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Liaocheng People\u2019s Hospital  Liaocheng Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shandong Provincial Hospital affiliated to Shandong University  Jinan Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2011.07.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2014.02.015"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309262"},{"issue":"6","key":"e_1_2_7_5_1","first-page":"1394","article-title":"Assessment of portal hypertension and high\u2010risk oesophageal varices with liver and spleen three\u2010dimensional multifrequency MR elastography in liver cirrhosis","volume":"24","author":"Ronot M","year":"2014","journal-title":"Eur 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