{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T12:59:36Z","timestamp":1769345976170,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:00:00Z","timestamp":1583884800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81460122"],"award-info":[{"award-number":["81460122"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate whether second\u2010look endoscopy (SLE)\u2010guided therapy could be used to prevent post\u2010endoscopic variceal ligation (EVL) early bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive cirrhotic patients with large esophageal varices (EV) receiving successful EVL for acute variceal bleeding (AVB) or secondary prophylaxis were enrolled. The patients were randomized into a SLE group and a non\u2010SLE group (NSLE) 10\u2009days after EVL. Additional endoscopic interventions as well as proton pump inhibitors and octreotide administration were applied based on the SLE findings. The post\u2010EVL early rebleeding and mortality rates were compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 252 patients were included in the final analysis. Post\u2010EVL early rebleeding (13.5% vs 4.8%, <jats:italic>P<\/jats:italic> = 0.016) and bleeding\u2010caused mortality (4.8% vs 0%, <jats:italic>P<\/jats:italic> = 0.013) were more frequently observed in the NSLE group than in the SLE group. However, post\u2010EVL early rebleeding and mortality rates were reduced by SLE in patients receiving EVL for AVB only but not in those receiving secondary prophylaxis. Patients with Child\u2010Pugh classification B to C at randomization (hazard ratio [HR] 8.77, <jats:italic>P<\/jats:italic> = 0.034), AVB at index EVL (HR 3.62, <jats:italic>P<\/jats:italic> = 0.003), discontinuation of non\u2010selective \u03b2\u2010blocker after randomization (HR 4.68, <jats:italic>P<\/jats:italic> = 0.001) and non\u2010SLE (HR 2.63, <jats:italic>P<\/jats:italic> = 0.046) were more likely to have post\u2010EVL early rebleeding. No serious adverse events occurred during SLE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SLE\u2010guided therapy reduces post\u2010EVL early rebleeding and mortality rates in cirrhotic patients with large EV receiving EVL for AVB.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12847","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T16:15:13Z","timestamp":1581092113000},"page":"170-178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Second\u2010look endoscopy\u2010guided therapy under sedation prevents early rebleeding after variceal ligation for acute variceal bleeding"],"prefix":"10.1111","volume":"21","author":[{"given":"An Jiang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Nanchang University  Nanchang Jiangxi Province 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University  Nanchang Jiangxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Nanchang University  Nanchang Jiangxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Nanchang University  Nanchang Jiangxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"You","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Nanchang University  Nanchang Jiangxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui Hai","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Nanchang University  Nanchang Jiangxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bu Shan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Nanchang University  Nanchang Jiangxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia Wei","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Nanchang University  Nanchang Jiangxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Bo","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Nanchang University  Nanchang Jiangxi Province 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