{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:24:30Z","timestamp":1767918270200,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to identify the differences in symptoms, high\u2010resolution manometry (HRM) characteristics, and the efficacy of peroral endoscopic myotomy (POEM) regarding patients' sex in achalasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients diagnosed with achalasia by HRM who underwent POEM and were followed up for more than 6 months were included. The individual characteristics, symptoms and signs, POEM findings, HRM results and potentially related complications in male and female patients were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prior to POEM, dysphagia was more severe in female than male patients (<jats:italic>P<\/jats:italic> =\u20090.044), while regurgitation was more severe (<jats:italic>P<\/jats:italic> =\u20090.013) and heartburn was more common in male patients (<jats:italic>P<\/jats:italic> =\u20090.003). Regarding HRM characteristics, the lower esophageal sphincter pressure (LESP) was higher (<jats:italic>P<\/jats:italic> =\u20090.01) and length of esophagus was shorter in female patients than in male patients. Eckardt scores, LESP and integrated relaxation pressure were significantly improved after the POEM procedure (<jats:italic>P<\/jats:italic> &lt;\u20090.001). No significant difference was observed between the sexes regarding the efficacy of POEM, reflux symptoms, HRM data and complications after POEM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Before they seek treatment, female patients with achalasia may experience severe dysphagia and male patients are more likely to experience heartburn and more severe regurgitation. POEM is a safe and effective option for treating both male and female patients with achalasia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12922","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T17:38:03Z","timestamp":1595266683000},"page":"490-497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sex differences in symptoms, high\u2010resolution manometry values and efficacy of peroral endoscopic myotomy in Chinese patients with achalasia"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9868-4014","authenticated-orcid":false,"given":"Ying","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0938-0447","authenticated-orcid":false,"given":"Bi Xing","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Su","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Rong","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5799-9220","authenticated-orcid":false,"given":"Liu Qin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu Province 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