{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:28:02Z","timestamp":1747182482682,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010580","name":"Department of Science and Technology, Hubei Provincial People's Government","doi-asserted-by":"publisher","award":["2019ACA133","2020FCA014"],"award-info":[{"award-number":["2019ACA133","2020FCA014"]}],"id":[{"id":"10.13039\/501100010580","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370550","81570530","81974078"],"award-info":[{"award-number":["81370550","81570530","81974078"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Abnormal liver function is a common form of extra\u2010pulmonary organ damage in patients with coronavirus disease 2019 (COVID\u201019). Patients with severe COVID\u201019 have a higher probability and progression of liver injury than those without severe disease. We aimed to evaluate the prognosis of liver injury in patients with COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively included 502 patients with laboratory\u2010confirmed SARS\u2010CoV\u20102 infection. Clinical features and survival of patients with and without liver injury were compared. Cox proportional hazards models were used to determine the variables that might have an effect on survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 502 patients enrolled, 301 patients had abnormal liver function with increased neutrophil count, C\u2010reactive protein, creatinine, troponin I (TnI), D\u2010dimer, lactose dehydrogenase and creatine kinase. Patients with abnormal liver functions had a higher mortality rate (28.9% vs 9.0%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), a higher ratio of male sex (65.1% vs 40.8%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and a higher chance of developing systemic inflammatory response syndrome (53.5% vs 41.3%, <jats:italic>P<\/jats:italic> = 0.007). Among patients with abnormal liver functions, patients with grade 2 liver damage (with both abnormal alanine aminotransferase or aspartate aminotransferase levels and abnormal alkaline phosphatase or gamma\u2010glutamyl transpeptidase levels)  had a higher ratio of male patients, elevated neutrophil count, procalcitonin, D\u2010dimer levels and mortality rate. Multivariate Cox regression analyses suggested that the grade of liver damage (hazard ratio: 1.377, 95% confidence interval: 1.000\u20101.896, <jats:italic>P<\/jats:italic> = 0.049) was an independent predictor of death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with COVID\u201019 and abnormal liver functions have a higher mortality than those with normal liver functions. Liver damage is an independent prognostic factor of COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12925","type":"journal-article","created":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T12:55:07Z","timestamp":1595768107000},"page":"512-518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Liver damage at admission is an independent prognostic factor for <scp>COVID<\/scp>\u201019"],"prefix":"10.1111","volume":"21","author":[{"given":"Liu Ying","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan, Hubei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui Kuan","family":"Chu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  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