{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:28:03Z","timestamp":1747182483396,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["Research Grant [SVV 260396]"],"award-info":[{"award-number":["Research Grant [SVV 260396]"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Over the past few years, mucosal healing (MH) has emerged as a promising goal in the treatment of pediatric patients with Crohn\u02bcs disease (CD). We aimed to assess whether combination therapy with infliximab (IFX) +\u2009azathioprine (AZA) was more effective than AZA therapy alone in achieving mucosal healing in pediatric patients with CD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Newly diagnosed pediatric patients with CD at the Department of Pediatrics in University Hospital in Hradec Kr\u00e1lov\u00e9 were retrospectively recruited (2000\u20102014). The patients were divided into two groups according to the therapy: (a) IFX\u2009+\u2009AZA\u2009\u00b1\u2009corticosteroids\u2009\u00b1\u20095\u2010aminosalicylic acid (5\u2010ASA) (n = 16); and (b) AZA\u2009\u00b1 corticosteroids\u2009\u00b1\u20095\u2010ASA (n = 40). The patients were also divided into two groups: \u201cMH\u201d and \u201cno MH,\u201d according to their MH status. MH was defined as the complete endoscopic disappearance of all mucosal ulcerations (including aphthous ulcerations) and the absence of any sign of mucosal inflammation in the terminal ileum and the large bowel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 56 patients, MH was observed in 56% (9\/16) treated with combined therapy in comparison with 15% (6\/40) of patients in the AZA group (<jats:italic>P<\/jats:italic> =\u20090.006). The median dose of AZA in both groups was 2.1\u2009mg\/kg per day. We observed eight adverse events in seven patients from the IFX\u2009+\u2009AZA group. Adverse effects were less common in the AZA group (<jats:italic>P<\/jats:italic> = 0.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Combined therapy (IFX\u2009+\u2009AZA) was more effective in achieving MH in pediatric CD than treatment with AZA alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12927","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T03:29:01Z","timestamp":1596598141000},"page":"705-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Infliximab plus azathioprine is more effective than azathioprine alone in achieving mucosal healing in pediatric patients with Crohn's disease"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2357-1116","authenticated-orcid":false,"given":"Jan","family":"Melek","sequence":"first","affiliation":[{"name":"Department of Pediatrics University Hospital Hradec Kr\u00e1lov\u00e9, Charles University, Faculty of Medicine  Hradec Kr\u00e1lov\u00e9 Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark\u00e9ta","family":"\u0160tanclov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Hospital Hradec Kr\u00e1lov\u00e9, Charles University, Faculty of Medicine  Hradec Kr\u00e1lov\u00e9 Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"D\u011bdek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Hospital Hradec Kr\u00e1lov\u00e9, Charles University, Faculty of Medicine  Hradec Kr\u00e1lov\u00e9 Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Mal\u00fd","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Hospital Hradec Kr\u00e1lov\u00e9, Charles University, Faculty of Medicine  Hradec Kr\u00e1lov\u00e9 Czech 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Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-304984"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20927"},{"key":"e_1_2_7_4_1","article-title":"Endoscopic healing after infliximab treatment for Crohn's disease provides a longer time to relapse","volume":"122","author":"D'Haens 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