{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:45:38Z","timestamp":1782297938700,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>In this study we aimed to compare the efficacy and safety of two personalized rescue therapies for <jats:italic>Helicobacter pylori<\/jats:italic> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An open\u2010label, single\u2010center, randomized controlled trial was conducted. Patients who had failed one or two regimens for <jats:italic>H. pylori<\/jats:italic> infection were randomized to receive a 14\u2010day bismuth\u2010containing quadruple therapy guided by antimicrobial susceptibility testing (AST) or personal medication history (PMH). In the AST group, either two of amoxicillin, clarithromycin, metronidazole or levofloxacin were prescribed according to the AST. In the PMH group, amoxicillin plus either levofloxacin or furazolidone were prescribed based on the patient's history of quinolone use. The primary outcomes were eradication rates confirmed by an urea breath test 6\u2009weeks after treatment. The secondary outcomes were adherence, incidence of adverse events (AE) and cost\u2010effectiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Altogether 164 with a positive culture received AST\u2010guided therapy and 192 received PMH\u2010guided therapy, respectively. Both AST\u2010 and PMH\u2010guided therapies achieved comparable eradication rate (intention\u2010to\u2010treat analysis: 78.10% vs 74.29%, <jats:italic>P<\/jats:italic> = 0.42; per\u2010protocol analysis: 87.10% vs 88.64%, <jats:italic>P<\/jats:italic> = 0.80). The AST clarithromycin regimen had a lower per\u2010protocol eradication rate than the levofloxacin (75.47% vs 96.30%, <jats:italic>P<\/jats:italic> = 0.03) or furazolidone\u2010containing regimen (75.47% vs 92.75%, <jats:italic>P<\/jats:italic> = 0.02). Both groups had high compliance with low incidences of AE, and PMH\u2010guided therapy had a lower medical cost.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AST\u2010guided therapy was not superior to PMH\u2010guided therapy as a second\u2010 or third\u2010line treatment for <jats:italic>H. pylori<\/jats:italic> infection. Considering the cost\u2010effectiveness, PMH therapy is clinically more favorable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12934","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T22:31:25Z","timestamp":1598308285000},"page":"549-557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Susceptibility\u2010guided quadruple therapy is not superior to medication history\u2010guided therapy for the rescue treatment of <i>Helicobacter pylori<\/i> infection: A randomized controlled trial"],"prefix":"10.1111","volume":"21","author":[{"given":"Chao Ran","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue Yue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Yan","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Nan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Juan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Xiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9556-8771","authenticated-orcid":false,"given":"Xiu Li","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9325-4808","authenticated-orcid":false,"given":"Yan 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