{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:03:35Z","timestamp":1760123015891,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to establish a novel prognostic long noncoding RNA (lncRNA) signature for hepatitis B virus\u2010related hepatocellular carcinoma (HBV\u2010HCC) patients after hepatectomy and to validate its prognostic efficacy compared with other clinical staging systems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Expression data of 374 HCC samples were retrieved from The Cancer Genome Atlas (TCGA) database. Cox regression analyses were performed to develop the lncRNA model. The expression levels of lncRNAs were detected by qualitative real\u2010time polymerase chain reaction (qRT\u2010PCR) in HBV\u2010HCC. Then the qRT\u2010PCR\u2010based signature and nomogram were constructed and compared with those of other clinical staging systems in a clinical cohort and qRT\u2010PCR, RNA fluorescent in situ hybridization and comprehensive bioinformatics analyses were conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The signature containing five lncRNAs was constructed through TCGA. This model showed the highest predictive efficacy in patients with HBV\u2010HCC. Compared with normal liver tissues, all lncRNAs were highly expressed in HBV\u2010HCC. A four\u2010lncRNA signature containing <jats:italic>LINC01116<\/jats:italic>, <jats:italic>DDX11\u2010AS1<\/jats:italic>, <jats:italic>LUCAT1<\/jats:italic> and <jats:italic>FIRRE<\/jats:italic> was developed based on the qRT\u2010PCR data in a clinical HBV\u2010HCC patient cohort. A Kaplan\u2010Meier analysis indicated that the low\u2010risk group had significantly longer overall survival than the high\u2010risk group. Additionally, the qRT\u2010PCR\u2010based four\u2010lncRNA formula was an independent prognostic factor and had better predictive efficacy for survival (area under the receiver operating characteristic curve 0.875) compared with other clinical staging systems in HBV\u2010HCC. The lncRNA\u2010mRNA co\u2010expression and enrichment analyses revealed the potential regulatory mechanisms of the lncRNA identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The four\u2010lncRNA model may be an effective prognostic signature and provides potential prognostic biomarkers and therapeutic targets for HBV\u2010HCC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12941","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T09:24:05Z","timestamp":1600766645000},"page":"650-663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prognostic effect of a novel long noncoding RNA signature and comparison with clinical staging systems for patients with hepatitis B virus\u2010related hepatocellular carcinoma after hepatectomy"],"prefix":"10.1111","volume":"21","author":[{"given":"Hao","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong Province China"},{"name":"Shandong Provincial Engineering and Technological Research Center for Liver Diseases Prevention and Control, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian Tian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong Province China"},{"name":"Shandong Provincial Engineering and Technological Research Center for Liver Diseases Prevention and Control, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue Min","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong Province China"},{"name":"Shandong Provincial Engineering and Technological Research Center for Liver Diseases Prevention and Control, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Yu","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong Province China"},{"name":"Shandong Provincial Engineering and Technological Research Center for Liver Diseases Prevention and Control, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Nan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong Province China"},{"name":"Shandong Provincial Engineering and Technological Research Center for Liver Diseases Prevention and Control, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian Ni","family":"Qi","sequence":"additional","affiliation":[{"name":"Shandong Provincial Engineering and Technological Research Center for Liver Diseases Prevention and Control, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong Province China"},{"name":"Department of Central Laboratory, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5843-9724","authenticated-orcid":false,"given":"Qiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong Province China"},{"name":"Shandong Provincial Engineering and Technological Research Center for Liver Diseases Prevention and Control, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng Yong","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong Province China"},{"name":"Shandong Provincial Engineering and Technological Research Center for Liver Diseases Prevention and Control, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-017-9799-9"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ssu.10017"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850815)56:4<918::AID-CNCR2820560437>3.0.CO;2-E"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007122"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005350300038"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10384"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29913"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-10-38"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.621"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2014.06.004"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.04.009"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.02.035"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030682"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2764"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10148-6"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i30.3426"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.3575"},{"issue":"5","key":"e_1_2_5_20_1","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1159\/000492507","article-title":"Identification of potential prognostic long non\u2010coding RNA biomarkers for predicting survival in patients with hepatocellular carcinoma","volume":"48","author":"Liao X","year":"2018","journal-title":"Cell Physiol Biochem."},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13863"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.10.029"},{"issue":"2","key":"e_1_2_5_23_1","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1002\/jcb.27557","article-title":"Construction and comprehensive analysis of dysregulated long non\u2010coding RNA\u2010associated competing endogenous RNA network in clear cell renal cell carcinoma","volume":"120","author":"Wang J","year":"2018","journal-title":"J Cell Biochem."},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn923"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15108-2"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-1991"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i32.5860"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.09.006"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.12.061"},{"key":"e_1_2_5_33_1","first-page":"19","article-title":"Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics","volume":"4","author":"Dhanasekaran R","year":"2012","journal-title":"Hepat Med."},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000430109"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2015.07.025"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24813"},{"issue":"6","key":"e_1_2_5_37_1","doi-asserted-by":"crossref","first-page":"BSR20181781","DOI":"10.1042\/BSR20181781","article-title":"Development and validation of a prognostic nomogram for early\u2010onset colon cancer","volume":"39","author":"Yu C","year":"2019","journal-title":"Biosci Rep."},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0586-4"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2016.07.003"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.02.012"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27697"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq1348"}],"container-title":["Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-2980.12941","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1751-2980.12941","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-2980.12941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T15:36:59Z","timestamp":1693841819000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1751-2980.12941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,27]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/1751-2980.12941"],"URL":"https:\/\/doi.org\/10.1111\/1751-2980.12941","archive":["Portico"],"relation":{},"ISSN":["1751-2972","1751-2980"],"issn-type":[{"type":"print","value":"1751-2972"},{"type":"electronic","value":"1751-2980"}],"subject":[],"published":{"date-parts":[[2020,10,27]]},"assertion":[{"value":"2020-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}