{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:42:23Z","timestamp":1762324943702,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy of transjugular intrahepatic portosystemic shunt (TIPS) and non\u2010TIPS therapy (endoscopy and\/or nonselective beta\u2010blockers [NSBB]) in patients with cirrhosis and active variceal hemorrhage who did not respond to high\u2010dose vasoactive drugs and required balloon tamponade for hemostasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of cirrhotic patients who did not respond to high\u2010dose vasoactive drugs and required balloon tamponade for hemostasis at five university hospitals in China between January 2011 and December 2018 were reviewed. Treatment outcomes were compared between the TIPS and the non\u2010TIPS groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment failure of variceal hemorrhage within 5\u2009days was reported in six patients of the non\u2010TIPS group (N\u00a0=\u00a070) and none of the TIPS group (N\u00a0=\u00a066) (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.028). The TIPS group had a higher 1\u2010year variceal rebleeding\u2010free rate compared with the non\u2010TIPS group (95.5% vs 60.0%, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). One patient treated with TIPS and nine with non\u2010TIPS therapy experienced rebleeding within 5\u2009days and 6\u2009weeks after the intervention (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.009). The cumulative 1\u2010year survival rate was higher in the TIPS group than in the non\u2010TIPS group (93.9% vs 78.6%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01). The TIPS group had a higher incidence of hepatic encephalopathy within one year compared with the non\u2010TIPS group (18.2% vs 4.3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.026).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For patients with cirrhosis and active variceal bleeding who do not respond to high\u2010dose vasoactive agents and require a balloon tamponade for hemostasis, TIPS may be an appropriate treatment choice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12978","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T11:07:44Z","timestamp":1614337664000},"page":"236-245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Transjugular intrahepatic portosystemic shunt in patients treated with a balloon tamponade for variceal hemorrhage without response to high doses of vasoactive drugs: A real\u2010world multicenter retrospective study"],"prefix":"10.1111","volume":"22","author":[{"given":"Jing Bin","family":"Ni","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Nanjing Medical University Drum Tower Clinical Medical School  Nanjing Jiangsu Province China"},{"name":"Department of Gastroenterology Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University  Wuxi Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Xing","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Northern Jiangsu People's Hospital  Yangzhou Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi Yao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Yan","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing Jiangsu Province 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