{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:27:30Z","timestamp":1761920850396,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Visceral fat is thought to play different roles in the carcinogenesis of the colon with peripheral fat. Our aim was to evaluate the association of body fat distribution measured by bioelectrical impedance analysis (BIA) with the incidence of colorectal adenoma (CRA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 410 asymptomatic participants who underwent a screening colonoscopy from July 2017 to December 2019 in our center were recruited, including 230 with adenomas and 180 without detected adenomas. The participants\u2019 body fat was measured by BIA, including their body fat mass (BFM), body fat percentage (BFP), and waist\u2010to\u2010hip ratio. Parameters of metabolic syndrome (MetS), including waist circumference, blood pressure, fasting blood glucose (FBG), blood level of triglyceride, cholesterol, and high\u2010density lipoprotein were measured as well.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>According to univariate analysis, age, male sex, body mass index, waist circumference, BFM, waist\u2010to\u2010hip ratio, blood pressure, and FBG were higher in the adenoma group than in the adenoma\u2010free group (<jats:italic>P<\/jats:italic> &lt;\u20090.05). On multivariate logistical analysis (adjusted for age, sex, smoking, drinking, and family history of CRC), a high waist\u2010to\u2010hip ratio was associated with a high incidence of CRA (odds ratio [OR] 1.84, 95% confidence interval [CI] 1.09\u20103.09, <jats:italic>P<\/jats:italic> = 0.02). Only a large waist circumference in components of MetS was independently associated with the incidence of CRA (OR 1.90, 95% CI 1.17\u20103.08, <jats:italic>P<\/jats:italic> = 0.01) in the multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Body fat distribution is associated with CRA, central obesity is a core risk factor for CRA in MetS. Chinese Clinical Trial Registration number: ChiCTR\u2010RRC\u201017010862.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12979","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T14:05:02Z","timestamp":1614780302000},"page":"222-229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association of body fat distribution and metabolic syndrome with the occurrence of colorectal adenoma: A <scp>case\u2010control<\/scp> study"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8604-4818","authenticated-orcid":false,"given":"Zhong Hui","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Surgery University of Hong Kong\u2010Shenzhen Hospital  Shenzhen Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui Xi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Hong Kong\u2010Shenzhen Hospital  Shenzhen Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Hong Kong\u2010Shenzhen Hospital  Shenzhen Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Hong Kong\u2010Shenzhen Hospital  Shenzhen Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Hong Kong\u2010Shenzhen Hospital  Shenzhen Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fion Siu Yin","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Hong Kong\u2010Shenzhen Hospital  Shenzhen Guangdong Province China"},{"name":"Department of Surgery, Li Ka Shing Faculty of Medicine University of Hong Kong  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe King Man","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Hong Kong\u2010Shenzhen Hospital  Shenzhen Guangdong Province China"},{"name":"Department of Surgery, Li Ka Shing Faculty of Medicine University of Hong Kong  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.0735"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1158\/1538-7445.AM2016-151","article-title":"Modeling the rise of intratumoral heterogeneity in growing, static, and regressing human colorectal polyps","volume":"76","author":"Sievers 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