{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:06:58Z","timestamp":1791828418048,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670491"],"award-info":[{"award-number":["81670491"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore alterations in fecal short\u2010chain fatty acids (SCFA) and gut microbiota in patients with diarrhea\u2010predominant irritable bowel disease (IBS\u2010D) and their relationships with clinical manifestations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 162 patients with IBS\u2010D and 66 healthy controls (HC). Their manifestations and psychological status were evaluated using the IBS severity scoring system and the Hospital Anxiety and Depression Scale (HADS). Colorectal visceral sensitivity was evaluated using a barostat. Systemic inflammation was evaluated using plasma cytokine levels. Fecal SCFA were quantified using ultra\u2010performance liquid chromatography\u2010tandem mass spectrometry, and fecal microbiota communities were analyzed using 16S rRNA sequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>More men presented with IBS\u2010D than women in our patient cohort. Patients with IBS\u2010D had more severe manifestations, higher HADS score, and a higher rate of previous infectious enteritis than HC. Notably, female patients had significantly higher HADS scores than male patients. Male patients had significantly higher levels of plasma interleukin (IL)\u201012, fecal propionate and colorectal visceral sensitivity than male HC, while no differences were observed between female patients and female HC. Fecal acetate, butyrate and valerate correlated with the initial visceral sensory threshold, stressors, and IL\u201010 and IL\u201012 levels. The propionate\u2010producing <jats:italic>Prevotella 9<\/jats:italic> genus was significantly increased in male patients and positively correlated with fecal propionate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Distinct sex\u2010based differences in clinical manifestations, fecal SCFA and microbiota richness are found in Chinese patients with IBS\u2010D, which may be used to diagnose dysbiosis in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12988","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T11:48:11Z","timestamp":1617709691000},"page":"246-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Sex\u2010based differences in fecal short\u2010chain fatty acid and gut microbiota in irritable bowel syndrome patients"],"prefix":"10.1111","volume":"22","author":[{"given":"Qing Hua","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuo Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Jin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi Wei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei Bo","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Systems Biomedicine, School of Basic Medical Sciences Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6886-6888","authenticated-orcid":false,"given":"Li Ping","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311240"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2019.04.007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.14271"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014513"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1501305112"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11010051"},{"issue":"3","key":"e_1_2_7_8_1","first-page":"307","article-title":"Guidelines \u2010 Rome III diagnostic criteria for functional gastrointestinal disorders","volume":"15","author":"Rome Foundation","year":"2006","journal-title":"J Gastrointest Liver Dis."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.142318000.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-017-0759-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2018.07.006"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12109"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.11.050"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2013.16"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2014.11.015"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","unstructured":"KuczynskiJ StombaughJ WaltersWA GonzalezA CaporasoJG KnightR.Using QIIME to analyze 16S rRNA gene sequences from microbial communities. 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