{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:51:12Z","timestamp":1775782272005,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Rapid gastric emptying (RGE) is diagnosed using nuclear medicine gastric emptying scintigraphy (GES). The clinical symptoms are non\u2010specific and its pathophysiology in the absence of gastric surgery is poorly understood. We aimed to evaluate the clinical characteristics associated with idiopathic RGE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>GES studies were reviewed from a database of 1958 4\u2010hour solid\u2010phase GES performed over an 8\u2010year period. RGE was defined as &lt;30% of the test meal remaining in the stomach at 1 hour. Patients who had had any gastric operation were excluded. A chart review was conducted to extract patients\u2019 baseline data and clinical characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1958 GES studies reviewed, 156 (8.0%) patients had RGE, and 534 (27.3%) had delayed gastric emptying (&gt;10% retained food at 4 h), respectively. Idiopathic RGE constituted 22.6% (156\/690) of all abnormal GES studies. The patients\u2019 average age at diagnosis was 54.0\u2009years and 53.8% of patients with RGE were female. Most (69.2%) of these studies were ordered with an initial clinical suspicion of gastroparesis, compared with only 12.2% with a suspicion of RGE. Among this idiopathic RGE cohort, 71.2% presented with symptoms of nausea, 42.9% with vomiting, 32.1% with abdominal pain, 21.2% with bloating and 17.9% with early satiety. Only 7.7% presented with diarrhea, 0.6% with palpitations and 0.6% with hypoglycemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Idiopathic RGE is an important differential diagnosis in patients with symptoms classically associated with gastroparesis. Few have postprandial diarrhea or palpitations as their presenting symptom. Further studies of idiopathic RGE syndrome are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12990","type":"journal-article","created":{"date-parts":[[2021,4,11]],"date-time":"2021-04-11T11:15:10Z","timestamp":1618139710000},"page":"329-333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical characteristics associated with idiopathic rapid gastric emptying in patients referred for gastric emptying studies"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5869-5878","authenticated-orcid":false,"given":"Ted","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Wake Forest School of Medicine  Winston\u2010Salem NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Gastroenterology \u2009Wake Forest School of Medicine  Winston\u2010Salem NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent","family":"Bones","sequence":"additional","affiliation":[{"name":"Department of \u2009Radiology Wake Forest School of Medicine  Winston\u2010Salem NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Luc Claude","family":"Urbain","sequence":"additional","affiliation":[{"name":"Department of \u2009Radiology Wake Forest School of Medicine  Winston\u2010Salem NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paige","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of \u2009Radiology Wake Forest School of Medicine  Winston\u2010Salem NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jared","family":"Rejeski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Gastroenterology \u2009Wake Forest School of Medicine  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