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Classical HPS includes juvenile polyposis syndrome, Peutz\u2013Jeghers syndrome, <jats:italic>PTEN<\/jats:italic> hamartoma tumor syndrome and hereditary mixed polyposis syndrome. Patients with HPS have a higher risk of GI and extra\u2010GI malignancies than the general population, although the underlying mechanisms remain unclear and are obviously different from the carcinogenesis of classical adenocarcinoma and colitis\u2010associated malignancy. In this review we aimed to clarify the risks, possible mechanism and endoscopic surveillance of HPS\u2010associated GI malignancies.<\/jats:p>","DOI":"10.1111\/1751-2980.13029","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T03:18:51Z","timestamp":1624072731000},"page":"444-451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hamartomatous polyposis syndrome associated malignancies: Risk, pathogenesis and endoscopic surveillance"],"prefix":"10.1111","volume":"22","author":[{"given":"Shuang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing 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