{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:28:13Z","timestamp":1747182493931,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The hepatic venous pressure gradient (HVPG) plays an important role in the treatment and prognosis of patients with cirrhosis. Our study aimed to develop and validate a nomogram for an HVPG &gt;12\u2009mmHg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was performed to create a nomogram for an HVPG &gt;12\u2009mmHg in a training cohort that was validated in another cohort. The discriminatory ability and calibration of the nomogram were tested using the C\u2010statistic, area under the receiver operating characteristic curve (AUROC) and calibration plots.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The nomogram was based on portosystemic shunts identified on computed tomography images, the etiology of cirrhosis and the Child\u2010Pugh grade. These parameters were significantly associated with an HVPG &gt;12\u2009mmHg (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 for both the training and validation cohorts). In the training cohort, the model showed good discrimination (C\u2010statistic, AUROC, and R<jats:sup>2<\/jats:sup> of 0.71, 0.71 and 0.13, respectively) and good calibration. The total cutoff value was 112 and the sensitivity and specificity were 57.1% and 77.6%, respectively. The application of the nomogram in the validation cohort still yielded good discrimination (C\u2010statistic 0.75 [95% confidence interval 0.61\u20100.89], AUROC 0.75, and R<jats:sup>2<\/jats:sup> 0.16) and good calibration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This nomogram is a convenient tool for predicting an HVPG &gt;12\u2009mmHg in patients with cirrhosis and can help clinicians quickly identify patients with decompensated cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13033","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T12:06:23Z","timestamp":1626523583000},"page":"488-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nomogram for hepatic venous pressure gradient in patients with cirrhosis"],"prefix":"10.1111","volume":"22","author":[{"given":"Li Li","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong Province China"},{"name":"Department of Gastroenterology Jining No. 1 People's Hospital  Jining Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang Chuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang Jun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[{"name":"Digestive Diseases Hospital of Shandong First Medical Uniersity  Jining Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Jining No. 1 People's Hospital  Jining Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Linyi People's Hospital  Linyi Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3247-7458","authenticated-orcid":false,"given":"Chun Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/bega.2000.0136"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2018.12.020"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.01.014"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.10.013"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.05.022"},{"issue":"1","key":"e_1_2_6_7_1","first-page":"160","article-title":"Consensus on clinical application of the hepatic venous pressure gradient in China (2018)","volume":"35","author":"Chinese Portal Hypertension Diagnosis and Monitoring Study Group (CHESS); 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