{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T10:06:33Z","timestamp":1777111593539,"version":"3.51.4"},"reference-count":98,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T00:00:00Z","timestamp":1630627200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:label\/><jats:p>The presence of portal vein thrombosis (PVT) has previously been considered a contraindication to the insertion of transjugular intrahepatic portosystemic shunts (TIPSS). However, patients with PVT may have portal hypertension complications and may thus benefit from TIPSS to reduce portal venous pressure. There is an increasing body of literature that discusses the techniques and outcomes of TIPSS in PVT. This review summarizes the techniques, indications and outcomes of TIPSS in PVT in published case reports, case series and comparative trials, especially regarding the reduction in portal hypertensive complications such as variceal bleeding. A comprehensive literature search was conducted using MEDLINE and PubMed databases. Manuscripts published in English between 1 January 1990 and 1 March 2021 were used. Abstracts were screened and data from potentially relevant articles analyzed. TIPSS in PVT has been reported with high levels of technical success, short\u2010term portal vein recanalization and long\u2010term PV patency and TIPSS patency outcomes. Several comparative studies, including randomized controlled trials, have shown favorable outcomes of TIPSS compared with non\u2010TIPSS treatment of PVT complications. Outcomes of TIPSS with PVT appear similar to those in TIPSS without PVT. However, TIPSS may be more technically difficult in the presence of PVT, and such procedures should be performed in expert high\u2010volume centers to mitigate the risk of procedural complications. The presence of PVT should no longer be considered a contraindication to TIPSS. TIPSS for PVT has been acknowledged as a therapeutic strategy in recent international guidelines, although further studies are needed before recommendations can be strengthened.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Portal vein thrombosis (PVT) is no longer a contraindication to the insertion of transjugular intrahepatic portosystemic shunts (TIPSS)<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>TIPSS often leads to the spontaneous dissolution of PVT, but can be combined with mechanical or pharmacological thrombectomy<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>TIPSS reduces portal hypertensive complications of PVT, such as variceal bleeding, and can also facilitate liver transplantation where PVT may otherwise interfere with vascular anastomoses<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Studies have shown favorable long\u2010term outcomes of TIPSS compared with TIPSS without PVT; as well as compared with non\u2010TIPSS treatment of PVT complications<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>TIPSS in PVT should be performed in high\u2010volume specialist centers due to technical difficulties<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13035","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T11:44:34Z","timestamp":1627559074000},"page":"506-519","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Transjugular intrahepatic portosystemic shunts in portal vein thrombosis: A review"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3627-4647","authenticated-orcid":false,"given":"Sern Wei","family":"Yeoh","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Northern Health  Melbourne Victoria Australia"},{"name":"School of Medical 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