{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T18:30:56Z","timestamp":1774117856058,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Esophagogastric junction contractile integral (EGJ\u2010CI) is a novel indicator to evaluate quantitatively the esophagogastric junction (EGJ) barrier function. We aimed to assess the role of EGJ\u2010CI in patients with refractory gastroesophageal reflux disease (GERD) symptoms and the correlation between EGJ\u2010CI and impedance\u2010pH monitoring characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total 82 patients with proton pump inhibitors (PPIs)\u2010refractory gastroesophageal reflux symptoms (heartburn or regurgitation) were enrolled. These patients were further divided into two groups based on their EGJ\u2010CI value (39\u2009mmHg\u00b7cm). The mean nocturnal baseline impedance (MNBI) was measured to explore its association with EGJ\u2010CI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median EGJ\u2010CI in patients with PPI\u2010refractory symptoms was 30.8\u2009mmHg\u00b7cm. EGJ\u2010CI was inversely correlated with acid exposure time and reflux episodes; while it was positively correlated with MNBI, distal contractile integral, lower esophageal sphincter basal pressure and integrated relaxation pressure. Patients were further divided into the high (n\u00a0=\u00a027) and low (n\u00a0=\u00a055) EGJ\u2010CI groups using a cut\u2010off value of 39.0\u2009mmHg\u00b7cm. Patients with a low EGJ\u2010CI had a lower MNBI level than those with a high EGJ\u2010CI (2703 \u03a9 vs 3545 \u03a9, <jats:italic>P<\/jats:italic> =\u20090.034).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with PPIs\u2010refractory symptoms, EGJ\u2010CI is associated with acid exposure and conventional high\u2010resolution manometry parameters. EGJ\u2010CI may play an important role in the diagnosis and treatment of patients with refractory GERD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13038","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T05:09:02Z","timestamp":1628831342000},"page":"529-535","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Esophagogastric junction contractile integral abnormalities in patients with proton pump inhibitor\u2010refractory symptoms"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9232-2212","authenticated-orcid":false,"given":"Yan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Changshu Hospital Affiliated to Soochow University, First People's Hospital of Changshu City  Changshu Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5799-9220","authenticated-orcid":false,"given":"Liu Qin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314722"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.12.014"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-311715"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199703273361306"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12267"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12925"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001205"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12703"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12477"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm16047"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12299"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00711.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2009.00940.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12638"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12899"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2011.09.002"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12757"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13267"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0689-6"},{"issue":"11","key":"e_1_2_7_21_1","first-page":"706","article-title":"Assessment of the esophagogastric junction (EGJ) using the EGJ contractile integral (EGJ\u2010CI) following per\u2010oral endoscopic myotomy (POEM) in achalasia","volume":"110","author":"Wang D","year":"2018","journal-title":"Rev Esp Enferm Dig."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12620"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.04.030"}],"container-title":["Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-2980.13038","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1751-2980.13038","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-2980.13038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T02:22:34Z","timestamp":1693362154000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1751-2980.13038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/1751-2980.13038"],"URL":"https:\/\/doi.org\/10.1111\/1751-2980.13038","archive":["Portico"],"relation":{},"ISSN":["1751-2972","1751-2980"],"issn-type":[{"value":"1751-2972","type":"print"},{"value":"1751-2980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"2021-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}