{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:04:58Z","timestamp":1791975898918,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["A2019510"],"award-info":[{"award-number":["A2019510"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970479"],"award-info":[{"award-number":["81970479"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>In this systematic review and meta\u2010analysis we aimed to determine the efficacy and safety of magnetic sphincter augmentation (MSA) in the management of refractory gastroesophageal reflux disease (rGERD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Literature search was conducted in PubMed, the Cochrane Library, EMBASE, Web of Science, OpenGrey and ClincalTrials.gov for single\u2010arm studies evaluating the efficacy and safety of MSA in rGERD or comparative studies with proton pump inhibitor (PPI) or laparoscopic Nissen fundoplication (LNF) serving as the control published until April 2020. Primary outcome was the rate of postoperative PPI use, and secondary outcomes included postoperative GERD\u2010health\u2010related quality of life (GERD\u2010HRQL), normalization of acid exposure time (AET) and incidence of procedure\u2010related adverse events (AE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten single\u2010arm studies, one randomized controlled trial and three cohort studies involving 1138 participants were included. Post\u2010MSA PPI withdrawal, significant GERD\u2010HRQL improvement and AET normalization were achieved in 87.0%, 88.0% and 75.0% of the patients, respectively. The incidence of postoperative dysphagia was 29% and endoscopic dilation was required in 7.4% of patients undergoing MSA. MSA showed a better efficacy in symptom control than PPI (PPI cessation: 91% vs 0%; GERD\u2010HRQL improvement: 81% vs 8%) and similar effectiveness but a lower risk of gas\u2010bloat syndrome (risk ratio [RR] 0.69, 95% confidence interval [CI] 0.51\u20100.93, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) and better reserved ability to belch (RR 1.48, 95% CI 0.76\u20102.86, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.25) compared with LNF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MSA was an effective and safe therapy for rGERD. Well\u2010designed randomized trials that compare the efficacy of MSA with other therapies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13063","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T09:01:37Z","timestamp":1635152497000},"page":"695-705","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Magnetic sphincter augmentation in treating refractory gastroesophageal reflux disease: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7902-291X","authenticated-orcid":false,"given":"Qian Jun","family":"Zhuang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou Guangdong Province 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