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In this study we aimed to summarize their clinicopathological characteristics, effective treatment and prognostic factors for patients with GB\u2010NEC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with GB\u2010NEC admitted to Shanghai Jiao Tong University Affiliated Sixth People's Hospital and Renji Hospital, School of Medicine, Shanghai Jiao Tong University from October 2012 to August 2020 were enrolled. Clinicopathological characteristics of our patients and those reported in previous studies were recorded. The Kaplan\u2010Meier method and univariate and multivariate Cox regression analyses were used for survival analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Altogether 15 patients from our hospitals and 47 patients from previous studies were included. A total of 55 patients who underwent surgical resection, including R<jats:sub>0<\/jats:sub> and non\u2010R<jats:sub>0<\/jats:sub> resection, had significantly longer overall survival compared with the other seven patients. A univariate analysis indicated that patients aged 60\u2009years or older, with jaundice, carcinoid syndrome, non\u2010R<jats:sub>0<\/jats:sub> resection, and advanced stage were associated with worse survival. A multivariate analysis showed that patients aged 60\u2009years or older, carcinoid syndrome and non\u2010R<jats:sub>0<\/jats:sub> resection, but not lymphadenectomy and adjuvant chemotherapy, were independently related to reduced survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>R<jats:sub>0<\/jats:sub> resection should be the first\u2010line treatment for GB\u2010NEC. Older age, carcinoid syndrome and non\u2010R<jats:sub>0<\/jats:sub> resection are independently associated with reduced survival after surgical resection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13088","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T09:10:07Z","timestamp":1645434607000},"page":"166-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinicopathological characteristics and prognostic factors of patients with primary gallbladder neuroendocrine carcinomas"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6985-2234","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai China"},{"name":"Department of Biliary\u2010Pancreatic Surgery, Renji Hospital 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