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This study aimed to identify predictors and to construct a nomogram for steatorrhea in idiopathic chronic pancreatitis (ICP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>ICP patients admitted to our hospital from January 2000 to December 2013 were enrolled in this retrospective\u2013prospective cohort study and randomly assigned to the training and validation cohorts. The cumulative rate of steatorrhea was calculated. A Cox proportional hazard regression model was used to identify predictors for steatorrhea and construct the nomogram. Internal and external validation of the nomogram was then performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 1633 ICP patients enrolled, with a median follow\u2010up duration of 9.8\u2009years and 20.8% (339\/1633) of patients developed steatorrhea following onset of ICP. Steatorrhea was observed in 93, 115, and 133 patients at 1, 3, and 5\u2009years following diagnosis of CP, with a cumulative rate of 6.5% (95% confidence interval [CI] 5.1%\u20137.9%), 8.0% (95% CI 6.2%\u20139.8%), and 9.3% (95% CI 6.6%\u201312.0%), respectively. Male sex (hazard ratio [HR] 2.479, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), diabetes mellitus at\/before diagnosis of ICP (HR 2.274, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003), and aged less than 18\u2009years at onset of ICP (HR 0.095, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were identified risk factors for steatorrhea. Initial manifestations were associated with development of steatorrhea. The nomogram was proven to have good concordance indexes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We identified predictors and developed a nomogram for predicting steatorrhea in ICP. It was recommended that high\u2010risk populations be followed up closely, which might contribute to the early diagnosis and treatment of PEI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13102","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T09:17:58Z","timestamp":1655284678000},"page":"331-340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Risk factor analysis and nomogram development for steatorrhea in idiopathic chronic pancreatitis"],"prefix":"10.1111","volume":"23","author":[{"given":"Yu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Jinling Hospital Medical School of Nanjing University  Nanjing Jiangsu Province China"},{"name":"Department of Gastroenterology, Changhai Hospital The Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao 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