{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T23:39:12Z","timestamp":1782430752378,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"8-9","license":[{"start":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T00:00:00Z","timestamp":1668297600000},"content-version":"vor","delay-in-days":104,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the clinical characteristics, biochemical parameters and the distribution of HLA\u2010DQ genotypes among adult patients with celiac disease (CD) in Northwest China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study retrospectively collected clinical, biochemical, and HLA\u2010DQ genotype of patients with CD from a tertiary hospital in Xinjiang Uygur Autonomous Region, China between March 2016 and December 2021. Small intestinal biopsy and serum\u2010specific antibodies were used to diagnose CD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 102 CD patients, 63.7% were women (female: male\u00a0=\u00a01.76:1), and the mean age was 47.3\u2009\u00b1\u200914.7\u2009years at diagnosis. Common gastrointestinal symptoms included abdominal pain (50.0%), diarrhea (39.2%), and abdominal distension (24.5%). While common extraintestinal manifestations were anemia (48.0%), osteopenia or osteoporosis (36.3%), and fatigue (35.3%). Approximately 34.3% of patients with CD had comorbidities, with the most common being thyroid diseases (18.6%). Biochemical profiles showed lower hemoglobin, higher platelet count, and 25\u2010hydroxyvitamin D (25[OH]D) deficiency. HLA\u2010DQ2\/DQ8 was detected among all 53 patients who underwent genotype testing; the frequency of the HLA\u2010DQ2.5, DQ2.2, and DQ8 haplotypes was 71.7%, 24.5%, and 3.8%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CD was more common among women. Clinical manifestations include primarily gastrointestinal symptoms, but extraintestinal manifestations were not uncommon. Lower hemoglobin level, higher platelet count, and 25[OH]D deficiency are the main biochemical manifestations. The HLA\u2010DQ2.5 and DQ2.2 haplotypes are the most common genotypes in CD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.13133","type":"journal-article","created":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T06:16:56Z","timestamp":1664691416000},"page":"506-515","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical presentation, biochemical profile, and <scp>HLA<\/scp> haplotype frequency of celiac disease among adults in Northwest China"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7173-9502","authenticated-orcid":false,"given":"Tian","family":"Shi","sequence":"first","affiliation":[{"name":"Xinjiang Medical University  Urumqi Xinjiang Uygur Autonomous Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology People's Hospital of Xinjiang 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